R Kothari1, F Solmi, J Treasure, N Micali. 1. Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, UK. radha.kothari.10@ucl.ac.uk
Abstract
BACKGROUND: There is a large body of evidence indicating that eating disorders (EDs) are characterized by particular neuropsychological profiles. We aimed to further explore whether impairments in neuropsychological functioning previously found in ED groups are present prior to onset, or are secondary to the disorder. Method This is the first study to explore neuropsychological functioning in children born to a mother with a lifetime ED, who are therefore at high risk of developing an ED, in a large cohort sample. We investigated intelligence and attention at age 8 years (n = 6201) and working memory (WM) and inhibition at age 10 years (6192) in children who are at high risk of developing an ED, compared to children who are not. RESULTS: The children of women with lifetime anorexia nervosa (AN) showed high full-scale and performance IQ, increased WM capacity, better visuo-spatial functioning, and decreased attentional control. The children of women with lifetime bulimia nervosa (BN) showed comparatively poor visuo-spatial functioning. CONCLUSIONS: Our findings suggest that high intelligence, increased WM capacity and impaired attentional control might be intermediate phenotypes on the pathway between genetic vulnerability and the development of an ED.
BACKGROUND: There is a large body of evidence indicating that eating disorders (EDs) are characterized by particular neuropsychological profiles. We aimed to further explore whether impairments in neuropsychological functioning previously found in ED groups are present prior to onset, or are secondary to the disorder. Method This is the first study to explore neuropsychological functioning in children born to a mother with a lifetime ED, who are therefore at high risk of developing an ED, in a large cohort sample. We investigated intelligence and attention at age 8 years (n = 6201) and working memory (WM) and inhibition at age 10 years (6192) in children who are at high risk of developing an ED, compared to children who are not. RESULTS: The children of women with lifetime anorexia nervosa (AN) showed high full-scale and performance IQ, increased WM capacity, better visuo-spatial functioning, and decreased attentional control. The children of women with lifetime bulimia nervosa (BN) showed comparatively poor visuo-spatial functioning. CONCLUSIONS: Our findings suggest that high intelligence, increased WM capacity and impaired attentional control might be intermediate phenotypes on the pathway between genetic vulnerability and the development of an ED.
Authors: Jari Lahti; Samuli Tuominen; Qiong Yang; Giulio Pergola; Shahzad Ahmad; Najaf Amin; Nicola J Armstrong; Alexa Beiser; Katharina Bey; Joshua C Bis; Eric Boerwinkle; Jan Bressler; Archie Campbell; Harry Campbell; Qiang Chen; Janie Corley; Simon R Cox; Gail Davies; Philip L De Jager; Eske M Derks; Jessica D Faul; Annette L Fitzpatrick; Alison E Fohner; Ian Ford; Myriam Fornage; Zachary Gerring; Hans J Grabe; Francine Grodstein; Vilmundur Gudnason; Eleanor Simonsick; Elizabeth G Holliday; Peter K Joshi; Eero Kajantie; Jaakko Kaprio; Pauliina Karell; Luca Kleineidam; Maria J Knol; Nicole A Kochan; John B Kwok; Markus Leber; Max Lam; Teresa Lee; Shuo Li; Anu Loukola; Tobias Luck; Riccardo E Marioni; Karen A Mather; Sarah Medland; Saira S Mirza; Mike A Nalls; Kwangsik Nho; Adrienne O'Donnell; Christopher Oldmeadow; Jodie Painter; Alison Pattie; Simone Reppermund; Shannon L Risacher; Richard J Rose; Vijay Sadashivaiah; Markus Scholz; Claudia L Satizabal; Peter W Schofield; Katharina E Schraut; Rodney J Scott; Jeannette Simino; Albert V Smith; Jennifer A Smith; David J Stott; Ida Surakka; Alexander Teumer; Anbupalam Thalamuthu; Stella Trompet; Stephen T Turner; Sven J van der Lee; Arno Villringer; Uwe Völker; Robert S Wilson; Katharina Wittfeld; Eero Vuoksimaa; Rui Xia; Kristine Yaffe; Lei Yu; Habil Zare; Wei Zhao; David Ames; John Attia; David A Bennett; Henry Brodaty; Daniel I Chasman; Aaron L Goldman; Caroline Hayward; M Arfan Ikram; J Wouter Jukema; Sharon L R Kardia; Todd Lencz; Markus Loeffler; Venkata S Mattay; Aarno Palotie; Bruce M Psaty; Alfredo Ramirez; Paul M Ridker; Steffi G Riedel-Heller; Perminder S Sachdev; Andrew J Saykin; Martin Scherer; Peter R Schofield; Stephen Sidney; John M Starr; Julian Trollor; William Ulrich; Michael Wagner; David R Weir; James F Wilson; Margaret J Wright; Daniel R Weinberger; Stephanie Debette; Johan G Eriksson; Thomas H Mosley; Lenore J Launer; Cornelia M van Duijn; Ian J Deary; Sudha Seshadri; Katri Räikkönen Journal: Mol Psychiatry Date: 2022-08-16 Impact factor: 13.437
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