BACKGROUND: The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT. METHODS: We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: <50, 50-74, and ≥75 nmol/l. Serum ionized calcium, magnesium, phosphate, and creatinine were divided into tertiles. RESULTS: Mean age ± SD was 44 ± 9 years at 5 years follow-up. Ninety out of 125 (72 %) patients were women. SHPT was present in 45 out of 114 (40 %) gastric bypass patients and in 11 out of 11 (100 %) duodenal switch patients. The prevalence was high in all vitamin D categories studied. An inverse association between ionized calcium and PTH was found. For the gastric bypass patients, the odds ratio for SHPT in the upper two tertiles of ionized calcium was 0.35; 95 % CI, 0.15-0.79; p = 0.011, compared with the lowest tertile. Supplements of vitamin D and calcium were not associated with a lower prevalence of SHPT at 5 years follow-up. CONCLUSIONS: The prevalence of SHPT was high 5 years after gastric bypass and duodenal switch. SHPT was inversely associated with serum ionized calcium, but not with vitamin D. The supplementation used was insufficient to compensate for the impaired calcium absorption after surgery.
BACKGROUND: The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT. METHODS: We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: <50, 50-74, and ≥75 nmol/l. Serum ionizedcalcium, magnesium, phosphate, and creatinine were divided into tertiles. RESULTS: Mean age ± SD was 44 ± 9 years at 5 years follow-up. Ninety out of 125 (72 %) patients were women. SHPT was present in 45 out of 114 (40 %) gastric bypass patients and in 11 out of 11 (100 %) duodenal switch patients. The prevalence was high in all vitamin D categories studied. An inverse association between ionizedcalcium and PTH was found. For the gastric bypass patients, the odds ratio for SHPT in the upper two tertiles of ionizedcalcium was 0.35; 95 % CI, 0.15-0.79; p = 0.011, compared with the lowest tertile. Supplements of vitamin D and calcium were not associated with a lower prevalence of SHPT at 5 years follow-up. CONCLUSIONS: The prevalence of SHPT was high 5 years after gastric bypass and duodenal switch. SHPT was inversely associated with serum ionizedcalcium, but not with vitamin D. The supplementation used was insufficient to compensate for the impaired calcium absorption after surgery.
Authors: Monica L Nelson; Lynn M Bolduc; Michelle E Toder; Donald M Clough; Susan S Sullivan Journal: Surg Obes Relat Dis Date: 2007-04-02 Impact factor: 4.734
Authors: Juan Ybarra; Joan Sánchez-Hernández; Ignasi Gich; Alberto De Leiva; Xavier Rius; Jose Rodríguez-Espinosa; Antonio Pérez Journal: Obes Surg Date: 2005-03 Impact factor: 4.129
Authors: Torgeir T Søvik; Erlend T Aasheim; Osama Taha; My Engström; Morten W Fagerland; Sofia Björkman; Jon Kristinsson; Kare I Birkeland; Tom Mala; Torsten Olbers Journal: Ann Intern Med Date: 2011-09-06 Impact factor: 25.391
Authors: Erlend T Aasheim; Sofia Björkman; Torgeir T Søvik; My Engström; Susanna E Hanvold; Tom Mala; Torsten Olbers; Thomas Bøhmer Journal: Am J Clin Nutr Date: 2009-05-13 Impact factor: 7.045
Authors: T T Søvik; O Taha; E T Aasheim; M Engström; J Kristinsson; S Björkman; C F Schou; H Lönroth; T Mala; T Olbers Journal: Br J Surg Date: 2010-02 Impact factor: 6.939
Authors: M Osima; T T Borgen; M Lukic; G Grimnes; R M Joakimsen; E F Eriksen; Å Bjørnerem Journal: Osteoporos Int Date: 2017-11-14 Impact factor: 4.507
Authors: Meera Shah; Anu Sharma; Robert A Wermers; Kurt A Kennel; Todd A Kellogg; Manpreet S Mundi Journal: Obes Surg Date: 2017-11 Impact factor: 4.129
Authors: Stephen Hewitt; Sjur Humerfelt; Torgeir T Søvik; Erlend T Aasheim; Hilde Risstad; Jon Kristinsson; Tom Mala Journal: Obes Surg Date: 2014-05 Impact factor: 4.129
Authors: K M Nakamura; E G C Haglind; J A Clowes; S J Achenbach; E J Atkinson; L J Melton; K A Kennel Journal: Osteoporos Int Date: 2013-08-03 Impact factor: 4.507