Literature DB >> 23012450

Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c.

William J Quinn1, Morris J Birnbaum.   

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Year:  2012        PMID： 23012450      PMCID： PMC3479556          DOI： 10.1073/pnas.1214113109

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  21 in total

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2.  Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

Authors:  Anders Sundqvist; Maria T Bengoechea-Alonso; Xin Ye; Vasyl Lukiyanchuk; Jianping Jin; J Wade Harper; Johan Ericsson
Journal:  Cell Metab       Date:  2005-06       Impact factor: 27.287

3.  Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

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Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

4.  Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

Authors:  Karla F Leavens; Rachael M Easton; Gerald I Shulman; Stephen F Previs; Morris J Birnbaum
Journal:  Cell Metab       Date:  2009-11       Impact factor: 27.287

5.  Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line.

Authors:  Hyuntae Yoo; Maciek R Antoniewicz; Gregory Stephanopoulos; Joanne K Kelleher
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6.  HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Authors:  Ioanna Papandreou; Rob A Cairns; Lucrezia Fontana; Ai Lin Lim; Nicholas C Denko
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

7.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Authors:  Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi V Dang
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Review 8.  Selective versus total insulin resistance: a pathogenic paradox.

Authors:  Michael S Brown; Joseph L Goldstein
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9.  Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Authors:  Erinn B Rankin; Jennifer Rha; Mary A Selak; Travis L Unger; Brian Keith; Qingdu Liu; Volker H Haase
Journal:  Mol Cell Biol       Date:  2009-06-15       Impact factor: 4.272

10.  SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

Authors:  Thomas Porstmann; Claudio R Santos; Beatrice Griffiths; Megan Cully; Mary Wu; Sally Leevers; John R Griffiths; Yuen-Li Chung; Almut Schulze
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2.  Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.

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Review 3.  Insulin signalling mechanisms for triacylglycerol storage.

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Review 4.  The pentose phosphate pathway and cancer.

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5.  mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

Authors:  Daorong Feng; Dou Yeon Youn; Xiaoping Zhao; Yanguang Gao; William J Quinn; Alus M Xiaoli; Yan Sun; Morris J Birnbaum; Jeffrey E Pessin; Fajun Yang
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Review 6.  Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.

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7.  Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.

Authors:  Heidi L Kenerson; Savitha Subramanian; Rebecca McIntyre; Machiko Kazami; Raymond S Yeung
Journal:  PLoS One       Date:  2015-02-03       Impact factor: 3.240

8.  A pathway approach to investigate the function and regulation of SREBPs.

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Journal:  Genes Nutr       Date:  2013-03-21       Impact factor: 5.523

9.  Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP).

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10.  TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.

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