| Literature DB >> 18249166 |
Michael S Brown1, Joseph L Goldstein.
Abstract
Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.Entities:
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Year: 2008 PMID： 18249166 DOI： 10.1016/j.cmet.2007.12.009
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287