BACKGROUND: Group B Streptococcus (GBS) and Escherichia coli cause serious bacterial infections (SBIs) and are associated with morbidity and mortality in newborn infants. Intrapartum antibiotic prophylaxis reduces early-onset SBIs caused by GBS. The effect of intrapartum antibiotic prophylaxis on late-onset SBIs caused by these organisms is unknown. METHODS: We examined all blood, urine and cerebrospinal fluid culture results from infants admitted from 1997 to 2010 to 322 neonatal intensive care units managed by the Pediatrix Medical Group. We identified infants with positive cultures for GBS or E. coli and compared the incidence of early- and late-onset SBI for each organism in the time period before (1997 to 2001) and after (2002 to 2010) universal intrapartum antibiotic prophylaxis recommendations. RESULTS: We identified 716,407 infants with cultures, 2520 (0.4%) with cultures positive for GBS and 2476 (0.3%) with cultures positive for E. coli. The incidence of GBS early-onset SBI decreased between 1997 to 2001 and 2002 to 2010 from 3.5 to 2.6 per 1000 admissions, and the incidence for E. coli early-onset SBI remained stable (1.4/1000 admissions in both time periods). Over the same time period, the incidence of GBS late-onset SBI increased from 0.8 to 1.1 per 1000 admissions, and incidence of E. coli late-onset SBI increased from 2.2 to 2.5 per 1000 admissions. CONCLUSIONS: In our cohort, the incidence of GBS early-onset SBI decreased, whereas the incidence of late-onset SBI for E. coli and GBS increased.
BACKGROUND:Group B Streptococcus (GBS) and Escherichia coli cause serious bacterial infections (SBIs) and are associated with morbidity and mortality in newborn infants. Intrapartum antibiotic prophylaxis reduces early-onset SBIs caused by GBS. The effect of intrapartum antibiotic prophylaxis on late-onset SBIs caused by these organisms is unknown. METHODS: We examined all blood, urine and cerebrospinal fluid culture results from infants admitted from 1997 to 2010 to 322 neonatal intensive care units managed by the Pediatrix Medical Group. We identified infants with positive cultures for GBS or E. coli and compared the incidence of early- and late-onset SBI for each organism in the time period before (1997 to 2001) and after (2002 to 2010) universal intrapartum antibiotic prophylaxis recommendations. RESULTS: We identified 716,407 infants with cultures, 2520 (0.4%) with cultures positive for GBS and 2476 (0.3%) with cultures positive for E. coli. The incidence of GBS early-onset SBI decreased between 1997 to 2001 and 2002 to 2010 from 3.5 to 2.6 per 1000 admissions, and the incidence for E. coli early-onset SBI remained stable (1.4/1000 admissions in both time periods). Over the same time period, the incidence of GBS late-onset SBI increased from 0.8 to 1.1 per 1000 admissions, and incidence of E. coli late-onset SBI increased from 2.2 to 2.5 per 1000 admissions. CONCLUSIONS: In our cohort, the incidence of GBS early-onset SBI decreased, whereas the incidence of late-onset SBI for E. coli and GBS increased.
Authors: Barbara J Stoll; Nellie I Hansen; Pablo J Sánchez; Roger G Faix; Brenda B Poindexter; Krisa P Van Meurs; Matthew J Bizzarro; Ronald N Goldberg; Ivan D Frantz; Ellen C Hale; Seetha Shankaran; Kathleen Kennedy; Waldemar A Carlo; Kristi L Watterberg; Edward F Bell; Michele C Walsh; Kurt Schibler; Abbot R Laptook; Andi L Shane; Stephanie J Schrag; Abhik Das; Rosemary D Higgins Journal: Pediatrics Date: 2011-04-25 Impact factor: 7.124
Authors: William P Goins; Thomas R Talbot; William Schaffner; Kathryn M Edwards; Allen S Craig; Stephanie J Schrag; Melissa K Van Dyke; Marie R Griffin Journal: Obstet Gynecol Date: 2010-06 Impact factor: 7.661
Authors: Karen M Edmond; Christina Kortsalioudaki; Susana Scott; Stephanie J Schrag; Anita K M Zaidi; Simon Cousens; Paul T Heath Journal: Lancet Date: 2012-01-04 Impact factor: 79.321
Authors: Hannah T Jordan; Monica M Farley; Allen Craig; Janet Mohle-Boetani; Lee H Harrison; Susan Petit; Ruth Lynfield; Ann Thomas; Shelley Zansky; Kenneth Gershman; Bernadette A Albanese; William Schaffner; Stephanie J Schrag Journal: Pediatr Infect Dis J Date: 2008-12 Impact factor: 2.129
Authors: Melissa K Van Dyke; Christina R Phares; Ruth Lynfield; Ann R Thomas; Kathryn E Arnold; Allen S Craig; Janet Mohle-Boetani; Ken Gershman; William Schaffner; Susan Petit; Shelley M Zansky; Craig A Morin; Nancy L Spina; Kathryn Wymore; Lee H Harrison; Kathleen A Shutt; Joseph Bareta; Sandra N Bulens; Elizabeth R Zell; Anne Schuchat; Stephanie J Schrag Journal: N Engl J Med Date: 2009-06-18 Impact factor: 91.245
Authors: L Nowell; C Moran; P B Smith; P Seed; B D Alexander; C M Cotten; J S Wiener; D K Benjamin Journal: J Perinatol Date: 2009-10-08 Impact factor: 2.521
Authors: Mike A Carl; I Malick Ndao; A Cody Springman; Shannon D Manning; James R Johnson; Brian D Johnston; Carey-Ann D Burnham; Erica Sodergren Weinstock; George M Weinstock; Todd N Wylie; Makedonka Mitreva; Sahar Abubucker; Yanjiao Zhou; Harold J Stevens; Carla Hall-Moore; Samuel Julian; Nurmohammad Shaikh; Barbara B Warner; Phillip I Tarr Journal: Clin Infect Dis Date: 2014-03-18 Impact factor: 9.079
Authors: Allison N Dammann; Anna B Chamby; Andrew J Catomeris; Kyle M Davidson; Hervé Tettelin; Jan-Peter van Pijkeren; Kathyayini P Gopalakrishna; Mary F Keith; Jordan L Elder; Adam J Ratner; Thomas A Hooven Journal: PLoS Pathog Date: 2021-03-08 Impact factor: 6.823
Authors: Stephen P Bergin; Joshua T Thaden; Jessica E Ericson; Heather Cross; Julia Messina; Reese H Clark; Vance G Fowler; Daniel K Benjamin; Christoph P Hornik; P Brian Smith Journal: Pediatr Infect Dis J Date: 2015-09 Impact factor: 3.806