Literature DB >> 23010594

Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein.

Kirill Tsirulnikov1, Natalia Abuladze, Ritu Vahi, Huma Hasnain, Martin Phillips, Christopher M Ryan, Ivo Atanasov, Kym F Faull, Ira Kurtz, Alexander Pushkin.   

Abstract

Aminoacylase 3 (AA3) mediates deacetylation of N-acetyl aromatic amino acids and mercapturic acids. Deacetylation of mercapturic acids of exo- and endobiotics are likely involved in their toxicity. AA3 is predominantly expressed in kidney, and to a lesser extent in liver, brain, and blood. AA3 has been recently reported to interact with the hepatitis C virus core protein (HCVCP) in the yeast two-hybrid system. Here we demonstrate that AA3 directly binds to HCVCP (K(d) ~10 μM) that may by implicated in HCV pathogenesis. AA3 also revealed a weak endopeptidase activity towards the N-terminus of HCVCP. Published by Elsevier B.V.

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Year:  2012        PMID： 23010594      PMCID： PMC3483449          DOI： 10.1016/j.febslet.2012.09.015

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  27 in total

1.  Structures of aminoacylase 3 in complex with acetylated substrates.

Authors:  Jennifer M Hsieh; Kirill Tsirulnikov; Michael R Sawaya; Nathaniel Magilnick; Natalia Abuladze; Ira Kurtz; Jeff Abramson; Alexander Pushkin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205

Review 2.  Impact of the N-terminal amino acid on targeted protein degradation.

Authors:  Thierry Meinnel; Alexandre Serero; Carmela Giglione
Journal:  Biol Chem       Date:  2006-07       Impact factor: 3.915

3.  Novel bifunctional hyperthermostable carboxypeptidase/aminoacylase from Pyrococcus horikoshii OT3.

Authors:  K Ishikawa; H Ishida; I Matsui; Y Kawarabayasi; H Kikuchi
Journal:  Appl Environ Microbiol       Date:  2001-02       Impact factor: 4.792

4.  Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.

Authors:  Kirill Tsirulnikov; Natalia Abuladze; Anatol Bragin; Kym Faull; Duilio Cascio; Robert Damoiseaux; Matthew J Schibler; Alexander Pushkin
Journal:  Toxicol Appl Pharmacol       Date:  2012-07-20       Impact factor: 4.219

5.  Purification and characterisation of a lactococcal aminoacylase.

Authors:  Peter Curley; Chris van der Does; Arnold J M Driessen; Jan Kok; D van Sinderen
Journal:  Arch Microbiol       Date:  2003-04-08       Impact factor: 2.552

6.  The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference*.

Authors:  A Hatzakis; S Wait; J Bruix; M Buti; M Carballo; M Cavaleri; M Colombo; E Delarocque-Astagneau; G Dusheiko; G Esmat; R Esteban; D Goldberg; C Gore; A S F Lok; M Manns; P Marcellin; G Papatheodoridis; A Peterle; D Prati; N Piorkowsky; M Rizzetto; F Roudot-Thoraval; V Soriano; H C Thomas; M Thursz; D Valla; P van Damme; I K Veldhuijzen; H Wedemeyer; L Wiessing; A R Zanetti; H L A Janssen
Journal:  J Viral Hepat       Date:  2011-09       Impact factor: 3.728

Review 7.  Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes.

Authors:  J McLauchlan
Journal:  J Viral Hepat       Date:  2000-01       Impact factor: 3.728

8.  Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity.

Authors:  Khaled Alsaleh; Pierre-Yves Delavalle; André Pillez; Gilles Duverlie; Véronique Descamps; Yves Rouillé; Jean Dubuisson; Czeslaw Wychowski
Journal:  J Virol       Date:  2010-10-13       Impact factor: 5.103

9.  Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets.

Authors:  John McLauchlan; Marius K Lemberg; Graham Hope; Bruno Martoglio
Journal:  EMBO J       Date:  2002-08-01       Impact factor: 11.598

10.  Ubiquitin-mediated degradation of hepatitis C virus core protein is regulated by processing at its carboxyl terminus.

Authors:  R Suzuki; K Tamura; J Li; K Ishii; Y Matsuura; T Miyamura; T Suzuki
Journal:  Virology       Date:  2001-02-15       Impact factor: 3.616
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