Literature DB >> 23006759

The Inactivation of intrinsic antibiotic resistance determinants widens the mutant selection window for quinolones in Stenotrophomonas maltophilia.

Guillermo García-León1, María B Sánchez, José L Martínez.   

Abstract

We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF and SmQnr presented levels of susceptibility similar to those of the wild-type strain. This indicates that inactivation of intrinsic resistance determinants might increase the chances for selecting resistant mutants at low antibiotic concentrations.

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Year:  2012        PMID： 23006759      PMCID： PMC3497180          DOI： 10.1128/AAC.01558-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance.

Authors:  M C Negri; M Lipsitch; J Blázquez; B R Levin; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

Review 2.  The mutant selection window and antimicrobial resistance.

Authors:  Karl Drlica
Journal:  J Antimicrob Chemother       Date:  2003-06-12       Impact factor: 5.790

3.  Regulatory regions of smeDEF in Stenotrophomonas maltophilia strains expressing different amounts of the multidrug efflux pump SmeDEF.

Authors:  Patricia Sanchez; Ana Alonso; Jose L Martinez
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

4.  Quinolone-resistant Haemophilus influenzae: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin.

Authors:  Xinying Li; Noriel Mariano; James J Rahal; Carl M Urban; Karl Drlica
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

Review 5.  Antibiotic-selective environments.

Authors:  F Baquero; M C Negri; M I Morosini; J Blázquez
Journal:  Clin Infect Dis       Date:  1998-08       Impact factor: 9.079

Review 6.  Selective compartments for resistant microorganisms in antibiotic gradients.

Authors:  F Baquero; M C Negri
Journal:  Bioessays       Date:  1997-08       Impact factor: 4.345

7.  Multiple antibiotic resistance in Stenotrophomonas maltophilia.

Authors:  A Alonso; J L Martínez
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

8.  Preservation of topoisomerase genetic sequences during in vivo and in vitro development of high-level resistance to ciprofloxacin in isogenic Stenotrophomonas maltophilia strains.

Authors:  Sylvia Valdezate; Ana Vindel; Juan Antonio Saéz-Nieto; Fernando Baquero; Rafael Cantón
Journal:  J Antimicrob Chemother       Date:  2005-05-31       Impact factor: 5.790

9.  Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia.

Authors:  A Alonso; J L Martínez
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

10.  Mutations in gyrA and parC QRDRs are not relevant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates.

Authors:  Anna Ribera; Antonio Doménech-Sanchez; Joaquim Ruiz; Vicente Javier Benedi; Ma Teresa Jimenez de Anta; Jordi Vila
Journal:  Microb Drug Resist       Date:  2002       Impact factor: 3.431
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  6 in total

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Authors:  Onur Özgenç
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Review 2.  Does Chlorination Promote Antimicrobial Resistance in Waterborne Pathogens? Mechanistic Insight into Co-Resistance and Its Implication for Public Health.

Authors:  Martins A Adefisoye; Ademola O Olaniran
Journal:  Antibiotics (Basel)       Date:  2022-04-22

3.  Overexpression of the Efflux Pumps SmeVWX and SmeDEF Is a Major Cause of Resistance to Co-trimoxazole in Stenotrophomonas maltophilia.

Authors:  María Blanca Sánchez; José Luis Martínez
Journal:  Antimicrob Agents Chemother       Date:  2018-05-25       Impact factor: 5.191

4.  A function of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots.

Authors:  Guillermo García-León; Alvaro Hernández; Sara Hernando-Amado; Peyman Alavi; Gabriele Berg; José Luis Martínez
Journal:  Appl Environ Microbiol       Date:  2014-08       Impact factor: 4.792

5.  The intrinsic resistome of bacterial pathogens.

Authors:  Jorge Olivares; Alejandra Bernardini; Guillermo Garcia-Leon; Fernando Corona; Maria B Sanchez; Jose L Martinez
Journal:  Front Microbiol       Date:  2013-04-30       Impact factor: 5.640

6.  Advances in the Microbiology of Stenotrophomonas maltophilia.

Authors:  Joanna S Brooke
Journal:  Clin Microbiol Rev       Date:  2021-05-26       Impact factor: 50.129
  6 in total

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