Literature DB >> 23006752

Effect of PTX3 and voriconazole combination in a rat model of invasive pulmonary aspergillosis.

Pietro Lo Giudice1, Silvia Campo, Rita De Santis, Giovanni Salvatori.   

Abstract

This study evaluated the pharmacological activity of PTX3, administered in combination with voriconazole, in a rat model of pulmonary aspergillosis. The data indicated additive therapeutic activities of these compounds, as demonstrated by the amelioration of respiratory function changes, reduction of lung fungal burden, and increased survival. Overall, we provide clear evidence that the combination of PTX3 with a suboptimal dose of voriconazole might represent a therapeutic option under those clinical conditions where the use of voriconazole alone is not warranted for efficacy and tolerability reasons.

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Year:  2012        PMID： 23006752      PMCID： PMC3497210          DOI： 10.1128/AAC.01000-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Combination antifungal therapy.

Authors:  Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191

2.  Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America.

Authors:  Thomas J Walsh; Elias J Anaissie; David W Denning; Raoul Herbrecht; Dimitrios P Kontoyiannis; Kieren A Marr; Vicki A Morrison; Brahm H Segal; William J Steinbach; David A Stevens; Jo-Anne van Burik; John R Wingard; Thomas F Patterson
Journal:  Clin Infect Dis       Date:  2008-02-01       Impact factor: 9.079

3.  Efficacy of PTX3 in a rat model of invasive aspergillosis.

Authors:  Pietro Lo Giudice; Silvia Campo; Antonio Verdoliva; Vincenzo Rivieccio; Franco Borsini; Rita De Santis; Giovanni Salvatori
Journal:  Antimicrob Agents Chemother       Date:  2010-07-12       Impact factor: 5.191

4.  Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.

Authors:  Cecilia Garlanda; Emilio Hirsch; Silvia Bozza; Antonietta Salustri; Marika De Acetis; Rachele Nota; Alessia Maccagno; Federica Riva; Barbara Bottazzi; Giuseppe Peri; Andrea Doni; Luca Vago; Marina Botto; Rita De Santis; Paolo Carminati; Gregorio Siracusa; Fiorella Altruda; Annunciata Vecchi; Luigina Romani; Alberto Mantovani
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

5.  Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation.

Authors:  Antonio Inforzato; Giuseppe Peri; Andrea Doni; Cecilia Garlanda; Alberto Mantovani; Antonio Bastone; Andrea Carpentieri; Angela Amoresano; Piero Pucci; Anja Roos; Mohamed R Daha; Silvia Vincenti; Grazia Gallo; Paolo Carminati; Rita De Santis; Giovanni Salvatori
Journal:  Biochemistry       Date:  2006-09-26       Impact factor: 3.162

Review 6.  Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.

Authors:  Susan Julie Howard; Maiken Cavling Arendrup
Journal:  Med Mycol       Date:  2010-08-26       Impact factor: 4.076

7.  Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors.

Authors:  Maria Simitsopoulou; Emmanuel Roilides; Fotini Paliogianni; Christodoulos Likartsis; John Ioannidis; Kalliopi Kanellou; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

8.  Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization.

Authors:  Antonio Inforzato; Vincenzo Rivieccio; Antonio P Morreale; Antonio Bastone; Antonietta Salustri; Laura Scarchilli; Antonio Verdoliva; Silvia Vincenti; Grazia Gallo; Caterina Chiapparino; Lucrezia Pacello; Eleonora Nucera; Ottaviano Serlupi-Crescenzi; Anthony J Day; Barbara Bottazzi; Alberto Mantovani; Rita De Santis; Giovanni Salvatori
Journal:  J Biol Chem       Date:  2008-01-25       Impact factor: 5.157

9.  Update on the optimal use of voriconazole for invasive fungal infections.

Authors:  Asma Lat; George R Thompson
Journal:  Infect Drug Resist       Date:  2011-02-03       Impact factor: 4.003

10.  Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals.

Authors:  Roberta Gaziano; Silvia Bozza; Silvia Bellocchio; Katia Perruccio; Claudia Montagnoli; Lucia Pitzurra; Giovanni Salvatori; Rita De Santis; Paolo Carminati; Alberto Mantovani; Luigina Romani
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191
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  7 in total

1.  Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.

Authors:  Emanuele Marra; Vitor L Sousa; Roberta Gaziano; M Lucrezia Pacello; Brunilde Arseni; Luigi Aurisicchio; Rita De Santis; Giovanni Salvatori
Journal:  Antimicrob Agents Chemother       Date:  2014-07-28       Impact factor: 5.191

Review 2.  Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis.

Authors:  Ana Oliveira-Coelho; Fernando Rodrigues; António Campos; João F Lacerda; Agostinho Carvalho; Cristina Cunha
Journal:  Front Microbiol       Date:  2015-05-05       Impact factor: 5.640

3.  A novel fungus concentration-dependent rat model for acute invasive fungal rhinosinusitis: an experimental study.

Authors:  Yuyan Yan; Zuotao Zhao; Hongfei Wan; Ruochen Wu; Jugao Fang; Honggang Liu
Journal:  BMC Infect Dis       Date:  2014-12-20       Impact factor: 3.090

Review 4.  The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis.

Authors:  Rémi Porte; Sadaf Davoudian; Fatemeh Asgari; Raffaella Parente; Alberto Mantovani; Cecilia Garlanda; Barbara Bottazzi
Journal:  Front Immunol       Date:  2019-04-12       Impact factor: 7.561

Review 5.  Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections.

Authors:  Raffaella Parente; Valentina Possetti; Marco Erreni; Francesca D'Autilia; Barbara Bottazzi; Cecilia Garlanda; Alberto Mantovani; Antonio Inforzato; Andrea Doni
Journal:  Front Immunol       Date:  2021-11-18       Impact factor: 7.561

Review 6.  The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects.

Authors:  Yuening Kang; Yuetian Yu; Liangjing Lu
Journal:  Mycobiology       Date:  2020-02-08       Impact factor: 1.858

7.  The Protective Role of the Long Pentraxin PTX3 in Spontaneously Hypertensive Rats with Heart Failure.

Authors:  Wei Chen; Ya-Se Zhuang; Chun-Xia Yang; Zhi-Cheng Fang; Bo-Yi Liu; Xiang Zheng; Ying-Ying Liao
Journal:  Cardiovasc Toxicol       Date:  2021-06-25       Impact factor: 3.231
  7 in total

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