Literature DB >> 20625145

Efficacy of PTX3 in a rat model of invasive aspergillosis.

Pietro Lo Giudice1, Silvia Campo, Antonio Verdoliva, Vincenzo Rivieccio, Franco Borsini, Rita De Santis, Giovanni Salvatori.   

Abstract

Pentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus. PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate. PTX3 enhanced the survival rate and reduced the lung fungal burden of infected rats in both therapeutic and prophylactic modalities. Thus, we extended the protective activity of PTX3 in pulmonary aspergillosis to corticosteroid-induced immunodeficiency, which is a relevant clinical condition in graft-versus-host disease and in solid organ transplant.

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Year:  2010        PMID： 20625145      PMCID： PMC2944572          DOI： 10.1128/AAC.00674-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model.

Authors:  M J Becker; S de Marie; D Willemse; H A Verbrugh; I A Bakker-Woudenberg
Journal:  J Clin Microbiol       Date:  2000-04       Impact factor: 5.948

2.  Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.

Authors:  Cecilia Garlanda; Emilio Hirsch; Silvia Bozza; Antonietta Salustri; Marika De Acetis; Rachele Nota; Alessia Maccagno; Federica Riva; Barbara Bottazzi; Giuseppe Peri; Andrea Doni; Luca Vago; Marina Botto; Rita De Santis; Paolo Carminati; Gregorio Siracusa; Fiorella Altruda; Annunciata Vecchi; Luigina Romani; Alberto Mantovani
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

3.  Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation.

Authors:  Antonio Inforzato; Giuseppe Peri; Andrea Doni; Cecilia Garlanda; Alberto Mantovani; Antonio Bastone; Andrea Carpentieri; Angela Amoresano; Piero Pucci; Anja Roos; Mohamed R Daha; Silvia Vincenti; Grazia Gallo; Paolo Carminati; Rita De Santis; Giovanni Salvatori
Journal:  Biochemistry       Date:  2006-09-26       Impact factor: 3.162

4.  Efficacy of prophylactic aerosol amphotericin B lipid complex in a rat model of pulmonary aspergillosis.

Authors:  C E Cicogna; M H White; E M Bernard; T Ishimura; M Sun; W P Tong; D Armstrong
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

Review 5.  New perspectives on the biology of acute GVHD.

Authors:  S Paczesny; D Hanauer; Y Sun; P Reddy
Journal:  Bone Marrow Transplant       Date:  2009-11-30       Impact factor: 5.483

6.  Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease.

Authors:  Carmen D'Angelo; Antonella De Luca; Teresa Zelante; Pierluigi Bonifazi; Silvia Moretti; Gloria Giovannini; Rossana Giulietta Iannitti; Silvia Zagarella; Silvia Bozza; Silvia Campo; Giovanni Salvatori; Luigina Romani
Journal:  J Immunol       Date:  2009-09-04       Impact factor: 5.422

7.  Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization.

Authors:  Antonio Inforzato; Vincenzo Rivieccio; Antonio P Morreale; Antonio Bastone; Antonietta Salustri; Laura Scarchilli; Antonio Verdoliva; Silvia Vincenti; Grazia Gallo; Caterina Chiapparino; Lucrezia Pacello; Eleonora Nucera; Ottaviano Serlupi-Crescenzi; Anthony J Day; Barbara Bottazzi; Alberto Mantovani; Rita De Santis; Giovanni Salvatori
Journal:  J Biol Chem       Date:  2008-01-25       Impact factor: 5.157

Review 8.  Changing landscape of invasive aspergillosis in allogeneic stem cell transplant recipients.

Authors:  E Jantunen; A Nihtinen; V-J Anttila
Journal:  Transpl Infect Dis       Date:  2008-02-11       Impact factor: 2.228

9.  Regulation of leukocyte recruitment by the long pentraxin PTX3.

Authors:  Livija Deban; Remo Castro Russo; Marina Sironi; Federica Moalli; Margherita Scanziani; Vanessa Zambelli; Ivan Cuccovillo; Antonio Bastone; Marco Gobbi; Sonia Valentino; Andrea Doni; Cecilia Garlanda; Silvio Danese; Giovanni Salvatori; Marica Sassano; Virgilio Evangelista; Barbara Rossi; Elena Zenaro; Gabriela Constantin; Carlo Laudanna; Barbara Bottazzi; Alberto Mantovani
Journal:  Nat Immunol       Date:  2010-03-07       Impact factor: 25.606

10.  Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals.

Authors:  Roberta Gaziano; Silvia Bozza; Silvia Bellocchio; Katia Perruccio; Claudia Montagnoli; Lucia Pitzurra; Giovanni Salvatori; Rita De Santis; Paolo Carminati; Alberto Mantovani; Luigina Romani
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191
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  16 in total

1.  Effect of PTX3 and voriconazole combination in a rat model of invasive pulmonary aspergillosis.

Authors:  Pietro Lo Giudice; Silvia Campo; Rita De Santis; Giovanni Salvatori
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

2.  The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection.

Authors:  María Velasco-de Andrés; Cristina Català; Sergi Casadó-Llombart; Mario Martínez-Florensa; Inês Simões; Joaquín García-Luna; Gustavo Mourglia-Ettlin; Óscar Zaragoza; Esther Carreras; Francisco Lozano
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

3.  Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.

Authors:  Emanuele Marra; Vitor L Sousa; Roberta Gaziano; M Lucrezia Pacello; Brunilde Arseni; Luigi Aurisicchio; Rita De Santis; Giovanni Salvatori
Journal:  Antimicrob Agents Chemother       Date:  2014-07-28       Impact factor: 5.191

4.  Development of a novel inhalational model of invasive pulmonary aspergillosis in rats and comparative evaluation of three biomarkers for its diagnosis.

Authors:  Suhail Ahmad; Ali A Al-Shaikh; Ziauddin Khan
Journal:  PLoS One       Date:  2014-06-23       Impact factor: 3.240

5.  Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study.

Authors:  Tommaso Mauri; Andrea Coppadoro; Michela Bombino; Giacomo Bellani; Vanessa Zambelli; Carla Fornari; Lorenzo Berra; Edward A Bittner; Ulrich Schmidt; Marina Sironi; Barbara Bottazzi; Paolo Brambilla; Alberto Mantovani; Antonio Pesenti
Journal:  Crit Care       Date:  2014-10-15       Impact factor: 9.097

Review 6.  Rodent Models of Invasive Aspergillosis due to Aspergillus fumigatus: Still a Long Path toward Standardization.

Authors:  Guillaume Desoubeaux; Carolyn Cray
Journal:  Front Microbiol       Date:  2017-05-16       Impact factor: 5.640

Review 7.  Immunomodulation as Therapy for Fungal Infection: Are We Closer?

Authors:  Qi Hui Sam; Wen Shan Yew; Chaminda J Seneviratne; Matthew Wook Chang; Louis Yi Ann Chai
Journal:  Front Microbiol       Date:  2018-07-25       Impact factor: 5.640

8.  Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.

Authors:  Yared H Kidane; Christopher Lawrence; T M Murali
Journal:  BMC Microbiol       Date:  2013-10-07       Impact factor: 3.605

9.  Efficacy of the combination of voriconazole and caspofungin in experimental pulmonary aspergillosis by different Aspergillus species.

Authors:  Ming Zhang; Xin Su; Wen-Kui Sun; Fei Chen; Xiao-Yong Xu; Yi Shi
Journal:  Mycopathologia       Date:  2013-12-06       Impact factor: 2.574

Review 10.  Current State of the Diagnosis of Invasive Pulmonary Aspergillosis in Lung Transplantation.

Authors:  Sabina Herrera; Shahid Husain
Journal:  Front Microbiol       Date:  2019-01-09       Impact factor: 5.640
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