Literature DB >> 23002448

Increase in rates of hospitalization due to laboratory-confirmed influenza among children and adults during the 2009-10 influenza pandemic.

Chad M Cox1, Tiffany D'Mello, Alejandro Perez, Arthur Reingold, Ken Gershman, Kimberly Yousey-Hindes, Kathryn E Arnold, Monica M Farley, Patricia Ryan, Ruth Lynfield, Craig Morin, Joan Baumbach, Emily B Hancock, Shelley Zansky, Nancy M Bennett, Ann Thomas, William Schaffner, Lyn Finelli.   

Abstract

BACKGROUND: The Emerging Infections Programs (EIP) network has conducted population-based surveillance for hospitalizations due to laboratory-confirmed influenza among children since 2003, with the network expanding in 2005 to include adults.
METHODS: From 15 April 2009 through 30 April 2010, the EIP conducted surveillance among 22.1 million people residing in 10 states. Incidence rates per 100 000 population were calculated using US Census Bureau data. Mean historic rates were calculated on the basis of previously published and unpublished EIP data.
RESULTS: During the 2009 pandemic of influenza A virus subtype H1N1 infection, rates of hospitalizations due to laboratory-confirmed influenza were 202, 88, 49, 31, 27, 36, 28, and 27 episodes per 100 000 among persons aged <6 months, 6-23 months, 2-4 years, 5-17 years, 18-49 years, 50-64 years, 65-74 years, and ≥75 years, respectively. Comparative mean rates from previous influenza seasons during which EIP conducted surveillance were 153, 53, 20, 6, 4, 8, 20, and 56 episodes per 100 000 among persons aged <6 months, 6-23 months, 2-4 years, 5-17 years, 18-49 years, 50-64 years, 65-74 years, and ≥75 years, respectively.
CONCLUSIONS: During the pandemic, rates of hospitalization due to laboratory-confirmed influenza among individuals aged 5-17 years and 18-49 years increased 5-fold and 6-fold, respectively, compared with mean rates from previous influenza seasons. Hospitalization rates for other pediatric and adult age groups increased, compared with mean rates from previous influenza seasons, whereas the rate among individuals aged ≥75 years decreased.

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Year:  2012        PMID: 23002448     DOI: 10.1093/infdis/jis517

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  20 in total

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2.  Differential mucosal IL-10-induced immunoregulation of innate immune responses occurs in influenza infected infants/toddlers and adults.

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4.  Estimating the Burden of Pandemic Infectious Disease: The Case of the Second Wave of Pandemic Influenza H1N1 in Forsyth County, North Carolina.

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7.  The Unrecognized Burden of Influenza in Young Kenyan Children, 2008-2012.

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8.  Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates.

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9.  Clinical characteristics and outcomes in hospitalized patients with respiratory viral co-infection during the 2009 H1N1 influenza pandemic.

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10.  The US Influenza Hospitalization Surveillance Network.

Authors:  Sandra S Chaves; Ruth Lynfield; Mary Lou Lindegren; Joseph Bresee; Lyn Finelli
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