Literature DB >> 22999415

Synthesis of β-ionone derived chalcones as potent antimicrobial agents.

Vishal Sharma1, Gurpreet Singh, Harpreet Kaur, Ajit K Saxena, Mohan Paul S Ishar.   

Abstract

A series of chalcones (3a-v) have been synthesized by condensation of β-ionone (1) with a variety of aldehydes (2a-v). The synthesized compounds have been screened for their in vitro antimicrobial activity against five bacterial and five fungal strains, using disc diffusion assay. The evaluated compounds display a wide range of activities, from completely inactive to the highly active compounds. Some of the compounds are also active against methicillin resistant staphylococcus aureus (MRSA).
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22999415     DOI： 10.1016/j.bmcl.2012.08.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  (E)-1-(2-Hy-droxy-6-meth-oxy-phen-yl)-3-(2,4,6-tri-meth-oxy-phen-yl)prop-2-en-1-one.

Authors:  Dongsoo Koh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-23

2.  (2E)-1-(3,5-Di-hydroxy-phen-yl)-3-(4-meth-oxy-phen-yl)prop-2-en-1-one.

Authors:  K S Ezhilarasi; D Reuben Jonathan; Shanmugam Sathya; K Prathebha; G Usha
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-04-26

3.  Synthesis, Antimicrobial, and Computational Evaluation of Novel Isobutylchalcones as Antimicrobial Agents.

Authors:  Afzal Basha Shaik; Rajendra Prasad Yejella; Shahanaaz Shaik
Journal:  Int J Med Chem       Date:  2017-12-26

4.  Chemical Constituents of Salix babylonica L. and Their Antibacterial Activity Against Gram-Positive and Gram-Negative Animal Bacteria.

Authors:  Eddy Nathalye González-Alamilla; Manases Gonzalez-Cortazar; Benjamín Valladares-Carranza; Marco Antonio Rivas-Jacobo; Camelia Alejandra Herrera-Corredor; Deyanira Ojeda-Ramírez; Adrian Zaragoza-Bastida; Nallely Rivero-Perez
Journal:  Molecules       Date:  2019-08-18       Impact factor: 4.411

5.  Botanical and Genetic Identification Followed by Investigation of Chemical Composition and Biological Activities on the Scabiosa atropurpurea L. Stem from Tunisian Flora.

Authors:  Soukaina Hrichi; Raja Chaabane-Banaoues; Sihem Bayar; Guido Flamini; Yassine Oulad El Majdoub; Domenica Mangraviti; Luigi Mondello; Ridha El Mzoughi; Hamouda Babba; Zine Mighri; Francesco Cacciola
Journal:  Molecules       Date:  2020-10-29       Impact factor: 4.411

6.  In vitro anticandidal activity and gas chromatography-mass spectrometry (GC-MS) screening of Vitex agnus-castus leaf extracts.

Authors:  Ibtisam Mohammed Ababutain; Azzah Ibrahim Alghamdi
Journal:  PeerJ       Date:  2021-01-04       Impact factor: 2.984

7.  (E)-1-(3,5-Di-meth-oxy-phen-yl)-3-(3-meth-oxy-phen-yl)prop-2-en-1-one.

Authors:  Seunghyun Ahn; Ha-Jin Lee; Yoongho Lim; Dongsoo Koh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-04-05

8.  (E)-1-(1-Hy-droxy-naphthalen-2-yl)-3-(2,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.

Authors:  Dongsoo Koh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-03-16

9.  (E)-3-(3,5-Dimeth-oxy-phen-yl)-1-(1-hy-droxy-naphthalen-2-yl)prop-2-en-1-one.

Authors:  Ha-Jin Lee; Yoongho Lim; Dongsoo Koh
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24

10.  Antibacterial activity of three newly-synthesized chalcones & synergism with antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus.

Authors:  Dragana D Božić; Marina Milenković; Branka Ivković; Ivana Ćirković
Journal:  Indian J Med Res       Date:  2014-07       Impact factor: 2.375
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