Literature DB >> 22998864

Implementing the 3Rs in neuroscience research: a reasoned approach.

Colin Blakemore1, Judy MaCarthur Clark, Timo Nevalainen, Michael Oberdorfer, Arthur Sussman.   

Abstract

The 3Rs--replacement, reduction, and refinement--are aimed at minimizing the welfare costs to animals used in research. Some neuroscientists fear that implementing the 3Rs will prohibit essential studies. Others view them as fundamental ethical principles that improve the quality of research. A regulatory system that integrates science and welfare is most likely to deliver public confidence.
Copyright © 2012 Elsevier Inc. All rights reserved.

Mesh:

Year:  2012        PMID: 22998864     DOI: 10.1016/j.neuron.2012.09.001

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  11 in total

Review 1.  Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering.

Authors:  Sahba Mobini; Young Hye Song; Michaela W McCrary; Christine E Schmidt
Journal:  Biomaterials       Date:  2018-05-11       Impact factor: 12.479

Review 2.  Application of the genome editing tool CRISPR/Cas9 in non-human primates.

Authors:  Xin Luo; Min Li; Bing Su
Journal:  Dongwuxue Yanjiu       Date:  2016-07-18

Review 3.  Brains, genes, and primates.

Authors:  Juan Carlos Izpisua Belmonte; Edward M Callaway; Sarah J Caddick; Patricia Churchland; Guoping Feng; Gregg E Homanics; Kuo-Fen Lee; David A Leopold; Cory T Miller; Jude F Mitchell; Shoukhrat Mitalipov; Alysson R Moutri; J Anthony Movshon; Hideyuki Okano; John H Reynolds; Dario Ringach; Terrence J Sejnowski; Afonso C Silva; Peter L Strick; Jun Wu; Feng Zhang
Journal:  Neuron       Date:  2015-05-06       Impact factor: 17.173

Review 4.  Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioral sciences.

Authors:  Timothy J Bussey; Lisa M Saksida; Christopher J Heath; Laura Lopez-Cruz
Journal:  Lab Anim (NY)       Date:  2021-06-17       Impact factor: 12.625

5.  Differential effects of dopaminergic drugs on spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine.

Authors:  Kiyoshi Ando; Chiyoko Nishime; Ryo Inoue; Eiko Nishinaka; Kenji Kawai; Koji Urano; Hideki Tsutsumi
Journal:  Behav Pharmacol       Date:  2017-12       Impact factor: 2.293

6.  Researchers' attitudes to the 3Rs-An upturned hierarchy?

Authors:  Nuno Henrique Franco; Peter Sandøe; I Anna S Olsson
Journal:  PLoS One       Date:  2018-08-15       Impact factor: 3.240

7.  Sensing and processing whisker deflections in rodents.

Authors:  Thomas F Burns; Ramesh Rajan
Journal:  PeerJ       Date:  2021-02-22       Impact factor: 2.984

8.  Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice.

Authors:  Nao Fukuwada; Miki Kanno; Satomi Yoshida; Kenjiro Seki
Journal:  AIMS Neurosci       Date:  2020-11-10

9.  Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research.

Authors:  Tania Ramos-Moreno; Javier G Lendínez; María José Pino-Barrio; Araceli Del Arco; Alberto Martínez-Serrano
Journal:  PLoS One       Date:  2012-12-31       Impact factor: 3.240

Review 10.  The Use of ex Vivo Rodent Platforms in Neuroscience Translational Research With Attention to the 3Rs Philosophy.

Authors:  Laura Lossi; Adalberto Merighi
Journal:  Front Vet Sci       Date:  2018-07-19
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