CONTEXT: Current laboratory parameters provide limited information about the prognosis of severely injured patients; therefore, novel laboratory parameters are needed. MATERIALS AND METHODS: We compared the morphological parameters of neutrophils and lymphocytes, and white blood cell (WBC) differential count between survivors and nonsurvivors within 7 days after admission. Multiple logistic regression analysis was conducted to identify independent prognostic factors for 7-day in-hospital mortality. RESULTS: Neutrophil cell size was significantly different between survivors and nonsurvivors (p = 0.04), whereas WBC count and differential were not significantly different. Multiple logistic regression showed that neutrophil cell size was a significant predictor of poor outcome. CONCLUSIONS: Neutrophil cell size at admission is a prognostic factor for 7-day in-hospital mortality in severely injured trauma patients, whereas conventional WBC count and differential have no prognostic value.
CONTEXT: Current laboratory parameters provide limited information about the prognosis of severely injured patients; therefore, novel laboratory parameters are needed. MATERIALS AND METHODS: We compared the morphological parameters of neutrophils and lymphocytes, and white blood cell (WBC) differential count between survivors and nonsurvivors within 7 days after admission. Multiple logistic regression analysis was conducted to identify independent prognostic factors for 7-day in-hospital mortality. RESULTS: Neutrophil cell size was significantly different between survivors and nonsurvivors (p = 0.04), whereas WBC count and differential were not significantly different. Multiple logistic regression showed that neutrophil cell size was a significant predictor of poor outcome. CONCLUSIONS: Neutrophil cell size at admission is a prognostic factor for 7-day in-hospital mortality in severely injured traumapatients, whereas conventional WBC count and differential have no prognostic value.
Authors: G P J van Hout; W W van Solinge; C M Gijsberts; M P J Teuben; P H C Leliefeld; M Heeres; F Nijhoff; S de Jong; L Bosch; S C A de Jager; A Huisman; P R Stella; G Pasterkamp; L J Koenderman; I E Hoefer Journal: Basic Res Cardiol Date: 2015-10-14 Impact factor: 17.165
Authors: Lillian Hesselink; Roy Spijkerman; Karlijn J P van Wessem; Leo Koenderman; Luke P H Leenen; Markus Huber-Lang; Falco Hietbrink Journal: World J Emerg Surg Date: 2019-05-29 Impact factor: 5.469
Authors: Esmaeil Mortaz; Seyed Sajjad Zadian; Mehri Shahir; Gert Folkerts; Johan Garssen; Sharon Mumby; Ian M Adcock Journal: Front Immunol Date: 2019-09-06 Impact factor: 7.561