BACKGROUND: Necrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine. METHODS: Calprotectin is a calcium and zinc-binding protein in human neutrophils. Its concentration rises in various organic bowel diseases in adults and is resistant to degradation and has been proposed as a useful, simple, and rapid diagnostic method of inflammatory bowel disease that shows gastrointestinal inflammation in children and adults. RESULTS: We found that infants with necrotizing enterocolitis had increased fecal calprotectin concentrations, and there was a correlation between calprotectin concentrations and severity of NEC. CONCLUSIONS: We concluded that fecal calprotectin is a useful marker for diagnosis and severity of NEC in preterm infants.
BACKGROUND:Necrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine. METHODS: Calprotectin is a calcium and zinc-binding protein in human neutrophils. Its concentration rises in various organic bowel diseases in adults and is resistant to degradation and has been proposed as a useful, simple, and rapid diagnostic method of inflammatory bowel disease that shows gastrointestinal inflammation in children and adults. RESULTS: We found that infants with necrotizing enterocolitis had increased fecal calprotectin concentrations, and there was a correlation between calprotectin concentrations and severity of NEC. CONCLUSIONS: We concluded that fecal calprotectin is a useful marker for diagnosis and severity of NEC in preterm infants.
Authors: B C MacQueen; R D Christensen; C C Yost; D K Lambert; V L Baer; M J Sheffield; P V Gordon; M J Cody; E Gerday; R Schlaberg; J Lowe; J G Shepherd Journal: J Perinatol Date: 2016-07-07 Impact factor: 2.521
Authors: Oluwabunmi O Olaloye; Peng Liu; Jessica M Toothaker; Blake T McCourt; Collin C McCourt; Jenny Xiao; Erica Prochaska; Spenser Shaffer; Lael Werner; Jordan Gringauz; Misty Good; Jeffrey D Goldsmith; Xiaojing An; Fujing Wang; Scott B Snapper; Dror Shouval; Kong Chen; George Tseng; Liza Konnikova Journal: J Exp Med Date: 2021-07-16 Impact factor: 14.307