Literature DB >> 22996590

Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

Susanna Kushnir1, Uschi Sundermann, Samir Yahiaoui, Andreas Brockmeyer, Petra Janning, Frank Schulz.   

Abstract

Not in the public domain: Site-directed mutagenesis of megasynthases was the key to the generation of a library of polyketides in bacteria. Redox derivatizations are used to change the bioactivity profile of the compounds.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22996590     DOI： 10.1002/anie.201202438

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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