BACKGROUND: Previous studies investigating the association of physical activity with risk of lung cancer reported conflicting results. In order to update and improve available evidence on any link, a meta-analysis was performed. METHOD: We searched the PubMed database for prospective cohort studies investigating the relation of physical activity with risk of lung cancer. The pooled relative risk (RR) with its 95% confidence intervals (95%CI) was used to assess the association. RESULTS: We included 14 prospective studies with a total of 1,644,305 participants, with 14,074 incident lung cancer cases documented during follow-up. Meta-analysis of all 14 studies suggested both high and medium levels of physical activity to be associated with decreased risk of lung cancer compared to the reference group with low level of physical activity (for high level, RR = 0.77, 95%CI 0.73-0.81, P < 0.001; for medium level, RR = 0.87, 95%CI 0.83-0.90, P < 0.001). Subgroup analyses by gender found obvious associations in both men and women. No publication bias was observed. CONCLUSION: Our findings suggest that high and medium levels of physical activity have a beneficial effect on lung cancer by reducing the overall risk of tumour development among both men and women.
BACKGROUND: Previous studies investigating the association of physical activity with risk of lung cancer reported conflicting results. In order to update and improve available evidence on any link, a meta-analysis was performed. METHOD: We searched the PubMed database for prospective cohort studies investigating the relation of physical activity with risk of lung cancer. The pooled relative risk (RR) with its 95% confidence intervals (95%CI) was used to assess the association. RESULTS: We included 14 prospective studies with a total of 1,644,305 participants, with 14,074 incident lung cancer cases documented during follow-up. Meta-analysis of all 14 studies suggested both high and medium levels of physical activity to be associated with decreased risk of lung cancer compared to the reference group with low level of physical activity (for high level, RR = 0.77, 95%CI 0.73-0.81, P < 0.001; for medium level, RR = 0.87, 95%CI 0.83-0.90, P < 0.001). Subgroup analyses by gender found obvious associations in both men and women. No publication bias was observed. CONCLUSION: Our findings suggest that high and medium levels of physical activity have a beneficial effect on lung cancer by reducing the overall risk of tumour development among both men and women.
Authors: Dan Lewer; Martin McKee; Antonio Gasparrini; Aaron Reeves; Cesar de Oliveira Journal: Eur J Public Health Date: 2017-12-01 Impact factor: 3.367
Authors: Darren R Brenner; Gord Fehringer; Zuo-Feng Zhang; Yuan-Chin Amy Lee; Travis Meyers; Keitaro Matsuo; Hidemi Ito; Paolo Vineis; Isabelle Stucker; Paolo Boffetta; Paul Brennan; David C Christiani; Nancy Diao; Yun-Chul Hong; Maria T Landi; Hal Morgenstern; Ann G Schwartz; Gad Rennert; Walid Saliba; John R McLaughlin; Curtis C Harris; Irene Orlow; Juan M Barros Dios; Alberto Ruano Raviña; Jack Siemiatycki; Anita Koushik; Michele Cote; Philip Lazarus; Guillermo Fernandez-Tardon; Adonina Tardon; Loïc Le Marchand; Hermann Brenner; Kai-Uwe Saum; Eric J Duell; Angeline S Andrew; Dario Consonni; Ann Olsson; Rayjean J Hung; Kurt Straif Journal: Cancer Epidemiol Date: 2018-11-13 Impact factor: 2.984