BACKGROUND: Early-onset Alzheimer's disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease. OBJECTIVE: To evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology. METHODS: In all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron-emission tomography (FDG-PET). RESULTS: Patients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions. CONCLUSIONS: In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.
BACKGROUND: Early-onset Alzheimer's disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease. OBJECTIVE: To evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology. METHODS: In all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron-emission tomography (FDG-PET). RESULTS:Patients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions. CONCLUSIONS: In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.
Authors: Lieke L Smits; Yolande A L Pijnenburg; Esther L G E Koedam; Annelies E van der Vlies; Ilona E W Reuling; Teddy Koene; Charlotte E Teunissen; Philip Scheltens; Wiesje M van der Flier Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472
Authors: Julie S Snowden; Cheryl L Stopford; Camille L Julien; Jennifer C Thompson; Yvonne Davidson; Linda Gibbons; Antonia Pritchard; Corinne L Lendon; Anna M Richardson; Anoop Varma; David Neary; David Mann Journal: Cortex Date: 2007-10 Impact factor: 4.027
Authors: Agostino Chiaravalloti; Giacomo Koch; Sofia Toniolo; Lorena Belli; Francesco Di Lorenzo; Sara Gaudenzi; Orazio Schillaci; Marco Bozzali; Giuseppe Sancesario; Alessandro Martorana Journal: Dement Geriatr Cogn Dis Extra Date: 2016-04-05
Authors: Aida Suárez-González; Manja Lehmann; Timothy J Shakespeare; Keir X X Yong; Ross W Paterson; Catherine F Slattery; Alexander J M Foulkes; Gil D Rabinovici; Eulogio Gil-Néciga; Florinda Roldán-Lora; Jonathan M Schott; Nick C Fox; Sebastian J Crutch Journal: Neurobiol Aging Date: 2016-04-25 Impact factor: 4.673