Literature DB >> 22988906

Synthesis of tri- and tetrasubstituted pyrazoles via Ru(II) catalysis: intramolecular aerobic oxidative C-N coupling.

Jiantao Hu1, Shi Chen, Yonghui Sun, Jing Yang, Yu Rao.   

Abstract

An unprecedented ruthenium(II)-catalyzed intramolecular oxidative C-N coupling method has been developed for the facile synthesis of a variety of synthetically challenging tri- and tetrasubstituted pyrazoles. Dioxygen gas is employed as the oxidant in this transformation. The reaction demonstrates excellent reactivity, functional group tolerance, and high yields.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22988906     DOI： 10.1021/ol3022353

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles.

Authors:  Vunnam Venkateswarlu; Jaspreet Kour; K A Aravinda Kumar; Praveen Kumar Verma; G Lakshma Reddy; Yaseen Hussain; Aliya Tabassum; Shilpi Balgotra; Sorav Gupta; Abhinandan D Hudwekar; Ram A Vishwakarma; Sanghapal D Sawant
Journal:  RSC Adv       Date:  2018-07-24       Impact factor: 4.036

2.  Vinylogous reactivity of enol diazoacetates with donor-acceptor substituted hydrazones. Synthesis of substituted pyrazole derivatives.

Authors:  Xinfang Xu; Peter Y Zavalij; Wenhao Hu; Michael P Doyle
Journal:  J Org Chem       Date:  2013-01-24       Impact factor: 4.354

3.  Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase.

Authors:  Yu Zhou; Jun Liu; Mingyue Zheng; Shuli Zheng; Chunyi Jiang; Xiaomei Zhou; Dong Zhang; Jihui Zhao; Deju Ye; Mingfang Zheng; Hualiang Jiang; Dongxiang Liu; Jian Cheng; Hong Liu
Journal:  Acta Pharm Sin B       Date:  2016-01-07       Impact factor: 11.413

Review 4.  Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020).

Authors:  Xuefei Li; Yanbo Yu; Zhude Tu
Journal:  Molecules       Date:  2021-02-24       Impact factor: 4.411

Review 5.  Styrylpyrazoles: Properties, Synthesis and Transformations.

Authors:  Pedro M O Gomes; Pedro M S Ouro; Artur M S Silva; Vera L M Silva
Journal:  Molecules       Date:  2020-12-12       Impact factor: 4.411

Review 6.  Current status of pyrazole and its biological activities.

Authors:  Mohd Javed Naim; Ozair Alam; Farah Nawaz; Md Jahangir Alam; Perwaiz Alam
Journal:  J Pharm Bioallied Sci       Date:  2016 Jan-Mar

7.  Copper-Catalyzed Syntheses of Pyrene-Pyrazole Pharmacophores and Structure Activity Studies for Tubulin Polymerization.

Authors:  Dinabandhu Sar; Indrajit Srivastava; Santosh K Misra; Fatemeh Ostadhossein; Parinaz Fathi; Dipanjan Pan
Journal:  ACS Omega       Date:  2018-06-13

8.  Intramolecular C-N Bond Formation via Thermal Arene C-H Bond Activation Supported by Au(III) Complexes.

Authors:  Julianna Mruk; Agata J Pacuła-Miszewska; Leszek Pazderski; Joanna Drogosz-Stachowicz; Anna E Janecka; Jacek Ścianowski
Journal:  Materials (Basel)       Date:  2021-03-29       Impact factor: 3.623
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.