Literature DB >> 22987648

Self-resistance to an antitumor antibiotic: a DNA glycosylase triggers the base-excision repair system in yatakemycin biosynthesis.

Hui Xu1, Wei Huang, Qing-Li He, Zhi-Xiong Zhao, Feng Zhang, Renxiao Wang, Jingwu Kang, Gong-Li Tang.   

Abstract

Resistance is (not) futile: The yatakemycin biosynthetic gene cluster involves the ytkR2 gene, which encodes a protein with homology to a recently discovered bacterial DNA glycosylase. Genetic validation in vivo, biochemical assays, and in vitro mutagenesis studies revealed that YtkR2 confers resistance for the bacteria by specifically recognizing and cleaving the YTM-modified base (see scheme).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22987648     DOI： 10.1002/anie.201204109

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  20 in total

1.  Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.

Authors:  Rongxin Shi; Elwood A Mullins; Xing-Xing Shen; Kori T Lay; Philip K Yuen; Sheila S David; Antonis Rokas; Brandt F Eichman
Journal:  EMBO J       Date:  2017-10-20       Impact factor: 11.598

Review 2.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

3.  Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.

Authors:  Yue Zhang; Wan-Hong Wen; Jin-Yue Pu; Man-Cheng Tang; Liwen Zhang; Chao Peng; Yuquan Xu; Gong-Li Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-16       Impact factor: 11.205

Review 4.  Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2018-06-18       Impact factor: 4.411

5.  Structure of a DNA glycosylase that unhooks interstrand cross-links.

Authors:  Elwood A Mullins; Garrett M Warren; Noah P Bradley; Brandt F Eichman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-10       Impact factor: 11.205

6.  Insights into conformational changes in AlkD bound to DNA with a yatakemycin adduct from computational simulations.

Authors:  Pavel Silvestrov; G Andrés Cisneros
Journal:  Theor Chem Acc       Date:  2018-05-12       Impact factor: 1.702

7.  The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.

Authors:  Elwood A Mullins; Rongxin Shi; Zachary D Parsons; Philip K Yuen; Sheila S David; Yasuhiro Igarashi; Brandt F Eichman
Journal:  Nature       Date:  2015-10-28       Impact factor: 49.962

8.  Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks.

Authors:  Xiaorong Chen; Yuedi Sun; Shan Wang; Kun Ying; Le Xiao; Kai Liu; Xiuli Zuo; Jing He
Journal:  Nucleic Acids Res       Date:  2020-01-24       Impact factor: 16.971

Review 9.  Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.

Authors:  Elwood A Mullins; Alyssa A Rodriguez; Noah P Bradley; Brandt F Eichman
Journal:  Trends Biochem Sci       Date:  2019-05-09       Impact factor: 13.807

10.  Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases.

Authors:  Noah P Bradley; Katherine L Wahl; Jacob L Steenwyk; Antonis Rokas; Brandt F Eichman
Journal:  mBio       Date:  2022-03-21       Impact factor: 7.786
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