Literature DB >> 22987056

Modulation of antioxidant enzyme expression by PTU-induced hypothyroidism in cerebral cortex of postnatal rat brain.

Shravani Bhanja1, Srikanta Jena.   

Abstract

This study aimed to elucidate the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameters and expression of antioxidant enzymes in cerebral cortex of rat brain during postnatal development. A significant decrease in levels of lipid peroxidation and H(2)O(2) were seen in 7 and 30 days old PTU-treated rats with respect to their controls. Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls. However, increase in translated product of CAT was seen in all age groups of PTU-treated rats. Glutathione peroxidase activity was decreased in 7 days and increased in 15 days old PTU-treated rats with respect to their control groups. Histological sections clearly show a decline in neuronal migration with neurons packed together in the hypothyroid group as compared to the control.

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Year:  2012        PMID： 22987056     DOI： 10.1007/s11064-012-0885-z

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  42 in total

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9.  Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus.

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  6 in total

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Review 3.  The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.

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4.  Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats.

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Journal:  Neurol Res Int       Date:  2016-12-26

Review 5.  Contribution of Brain Tissue Oxidative Damage in Hypothyroidism-associated Learning and Memory Impairments.

Authors:  Yousef Baghcheghi; Hossein Salmani; Farimah Beheshti; Mahmoud Hosseini
Journal:  Adv Biomed Res       Date:  2017-05-22

6.  Lack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring.

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  6 in total

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