Literature DB >> 22983651

Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases.

Ning Lang1, Hui Shu Yuan, Hong Lei Wang, Jing Liao, Man Li, Fu Xin Guo, Shan Shi, Zhong Qiang Chen.   

Abstract

OBJECTIVE: To investigate the characteristics of epidemiological distribution of the ossification of the ligamentum flavum (OLF) in the thoracic spine including the incidence, segmental distribution, and shape.
METHODS: Chest spiral computed tomography scans of 993 cases (male 506, female 487, mean age 60 years, range 5-102 years) who presented due to chest symptoms were analyzed with axial slices combined with sagittal slices. The conditions of OLF in the thoracic spine, including segments, thickness, location, and dural sac compression, were recorded. Prevalence was standardized according to the "Age Structure of Population in Beijing 2008".
RESULTS: Among the population investigated, the standardized prevalence rate was 63.9 %. The standardized prevalence rate for males (68.5 %) was higher than that for females (59.0 %). The highest prevalence rate of OLF was in the 50-59 years age group (79.2 %); however, high density originated it can be found in individuals aged 10-19 years. The comparison of different thoracic segments showed that T10-11 (44.0 %) and T11-12 (41.6 %) had the highest prevalence rates.
CONCLUSION: The prevalence of ossification of the ligamentum flavum was highest in the 50-59 years group, but also occurred in early years. OLF occurs more frequently in the lower than in the upper and middle thoracic regions and its prevalence increases with aging.

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Year:  2012        PMID: 22983651      PMCID: PMC3631053          DOI: 10.1007/s00586-012-2492-8

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  20 in total

1.  Spinal cord compression secondary to ossified ligamentum flavum.

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Journal:  J Spinal Disord       Date:  1989-12

2.  MRI of ossification of ligamentum flavum.

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Journal:  J Comput Assist Tomogr       Date:  1992 Jan-Feb       Impact factor: 1.826

3.  Thoracic ossification of the posterior longitudinal ligament, ossification of the yellow ligament from T9-T12 with superimposed acute T10/T11 disc herniation: controversies in surgical management.

Authors:  N Epstein
Journal:  J Spinal Disord       Date:  1996-10

4.  Clinical analysis and prognostic study of ossified ligamentum flavum of the thoracic spine.

Authors:  K Shiokawa; J Hanakita; H Suwa; M Saiki; M Oda; M Kajiwara
Journal:  J Neurosurg       Date:  2001-04       Impact factor: 5.115

5.  The effect of mechanical stress on hypertrophy of the lumbar ligamentum flavum.

Authors:  S Fukuyama; T Nakamura; T Ikeda; K Takagi
Journal:  J Spinal Disord       Date:  1995-04

6.  Ossification in the cephalic attachment of the ligamentum flavum. An anatomical and CT study.

Authors:  D M Williams; T O Gabrielsen; J T Latack; W Martel; J E Knake
Journal:  Radiology       Date:  1984-02       Impact factor: 11.105

7.  Ossification of thoracic ligamenta flava.

Authors:  S Kudo; M Ono; W J Russell
Journal:  AJR Am J Roentgenol       Date:  1983-07       Impact factor: 3.959

8.  Myelopathy due to ossification or calcification of the ligamentum flavum: radiologic and histologic evaluations.

Authors:  K Miyasaka; K Kaneda; S Sato; Y Iwasaki; S Abe; H Takei; M Tsuru; K Tashiro; H Abe; Y Fujioka
Journal:  AJNR Am J Neuroradiol       Date:  1983 May-Jun       Impact factor: 3.825

9.  Prevalence, distribution, and morphology of ossification of the ligamentum flavum: a population study of one thousand seven hundred thirty-six magnetic resonance imaging scans.

Authors:  Jiong Jiong Guo; Keith D K Luk; Jaro Karppinen; Huilin Yang; Kenneth M C Cheung
Journal:  Spine (Phila Pa 1976)       Date:  2010-01-01       Impact factor: 3.468

10.  Thoracic myelopathy caused by ossification of the ligamentum flavum: a report of 18 cases.

Authors:  Karim Ben Hamouda; Hafedh Jemel; Slim Haouet; Moncef Khaldi
Journal:  J Neurosurg       Date:  2003-09       Impact factor: 5.115

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  33 in total

1.  Two novel BMP-2 variants identified in patients with thoracic ossification of the ligamentum flavum.

Authors:  Xiaochen Qu; Zhongqiang Chen; Dongwei Fan; Shen Xiang; Chuiguo Sun; Yan Zeng; Weishi Li; Zhaoqing Guo; Qiang Qi; Woquan Zhong; Yun Jiang
Journal:  Eur J Hum Genet       Date:  2017-02-01       Impact factor: 4.246

2.  Clinically significant radiographic parameter for thoracic myelopathy caused by ossification of the ligamentum flavum.

Authors:  Byung-Jou Lee; Jin Hoon Park; Sang-Ryong Jeon; Seung-Chul Rhim; Sung Woo Roh
Journal:  Eur Spine J       Date:  2018-09-06       Impact factor: 3.134

3.  The CT and intraoperative observation of pedicel-ossification tunnel in 151 cases of thoracic spinal stenosis from ossification of ligamentum flavum.

Authors:  Ying Zhao; Yuan Xue; Nianke Shi; Yaqi Zong; Zhong Yang; Dong He; Yi Wang; Huairong Ding; Zhiyang Li; Yanming Tang
Journal:  Eur Spine J       Date:  2014-03-08       Impact factor: 3.134

4.  A diagnostic study of thoracic myelopathy due to ossification of ligamentum flavum.

Authors:  Fabo Feng; Chuiguo Sun; ZhongQiang Chen
Journal:  Eur Spine J       Date:  2015-03-06       Impact factor: 3.134

Review 5.  Recurrence of ossification of ligamentum flavum at the same intervertebral level in the thoracic spine: a report of two cases and review of the literature.

Authors:  Haruo Kanno; Tadahisa Takahashi; Toshimi Aizawa; Ko Hashimoto; Eiji Itoi; Hiroshi Ozawa
Journal:  Eur Spine J       Date:  2017-08-24       Impact factor: 3.134

Review 6.  A systematic review of complications in thoracic spine surgery for ossification of ligamentum flavum.

Authors:  Xiaofei Hou; Zhongqiang Chen; Chuiguo Sun; Guangwu Zhang; Sijun Wu; Zheng Liu
Journal:  Spinal Cord       Date:  2017-12-28       Impact factor: 2.772

7.  Is T9-11 the true thoracolumbar transition zone?

Authors:  J Murphy; E McLoughlin; A M Davies; S L James; R Botchu
Journal:  J Clin Orthop Trauma       Date:  2019-10-10

8.  Clinical characteristics and surgical outcome of thoracic myelopathy caused by ossification of the ligamentum flavum: a retrospective analysis of 85 cases.

Authors:  Z Li; D Ren; Y Zhao; S Hou; L Li; S Yu; T Hou
Journal:  Spinal Cord       Date:  2015-08-04       Impact factor: 2.772

9.  Association analysis and functional study of COL6A1 single nucleotide polymorphisms in thoracic ossification of the ligamentum flavum in the Chinese Han population.

Authors:  Xiaochen Qu; Xiaofei Hou; Zhongqiang Chen; Guanghui Chen; Tianqi Fan; Xiaoxi Yang
Journal:  Eur Spine J       Date:  2021-07-21       Impact factor: 3.134

10.  Cervical Ossification of Ligamentum Flavum: Elaborating an Underappreciated but Occasional Contributor to Myeloradiculopathy in Aging Population Based on Synthesis of Individual Participant Data.

Authors:  Baoliang Zhang; Guanghui Chen; Xi Chen; Chuiguo Sun; Zhongqiang Chen
Journal:  Clin Interv Aging       Date:  2021-05-24       Impact factor: 4.458

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