Literature DB >> 22983555

Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.

Adrian Kee Keong Teo1, Rohit N Kulkarni.   

Abstract

Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22983555      PMCID： PMC3474931          DOI： 10.1038/emboj.2012.265

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  10 in total

Review 1.  Networking with AKAPs: context-dependent regulation of anchored enzymes.

Authors:  Emily J Welch; Brian W Jones; John D Scott
Journal:  Mol Interv       Date:  2010-04

2.  Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring.

Authors:  Omar M Faruque; Dung Le-Nguyen; Anne-Dominique Lajoix; Eric Vives; Pierre Petit; Dominique Bataille; El-Habib Hani
Journal:  Am J Physiol Cell Physiol       Date:  2008-12-10       Impact factor: 4.249

3.  AKAP150-anchored PKA activity is important for LTD during its induction phase.

Authors:  Yuan Lu; Mingxu Zhang; Indra A Lim; Duane D Hall; Margaret Allen; Yuliya Medvedeva; G Stanley McKnight; Yuriy M Usachev; Johannes W Hell
Journal:  J Physiol       Date:  2008-07-10       Impact factor: 5.182

Review 4.  Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells.

Authors:  P M Jones; S J Persaud
Journal:  Endocr Rev       Date:  1998-08       Impact factor: 19.871

Review 5.  Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins.

Authors:  Guillaume Pidoux; Kjetil Taskén
Journal:  J Mol Endocrinol       Date:  2010-02-11       Impact factor: 5.098

6.  A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.

Authors:  Yuan Lu; Xiang-ming Zha; Eun Young Kim; Scott Schachtele; Michael E Dailey; Duane D Hall; Stefan Strack; Steven H Green; Dax A Hoffman; Johannes W Hell
Journal:  J Biol Chem       Date:  2011-06-07       Impact factor: 5.157

7.  Anchoring of protein kinase A facilitates hormone-mediated insulin secretion.

Authors:  L B Lester; L K Langeberg; J D Scott
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

8.  Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation.

Authors:  L B Lester; M C Faux; J B Nauert; J D Scott
Journal:  Endocrinology       Date:  2001-03       Impact factor: 4.736

9.  Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion.

Authors:  Oleg Dyachok; Olof Idevall-Hagren; Jenny Sågetorp; Geng Tian; Anne Wuttke; Cécile Arrieumerlou; Göran Akusjärvi; Erik Gylfe; Anders Tengholm
Journal:  Cell Metab       Date:  2008-07       Impact factor: 27.287

10.  Anchored phosphatases modulate glucose homeostasis.

Authors:  Simon A Hinke; Manuel F Navedo; Allison Ulman; Jennifer L Whiting; Patrick J Nygren; Geng Tian; Antonio J Jimenez-Caliani; Lorene K Langeberg; Vincenzo Cirulli; Anders Tengholm; Mark L Dell'Acqua; L Fernando Santana; John D Scott
Journal:  EMBO J       Date:  2012-08-31       Impact factor: 11.598
  10 in total
  1 in total

1.  Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3β signalling pathway in diabetes mellitus.

Authors:  Yan-Rong Zhu; Xiao-Xin Jiang; Peng Ye; Zhi-Mei Wang; Yaguo Zheng; Zhizhong Liu; Shao-Liang Chen; Dai-Min Zhang
Journal:  J Cell Mol Med       Date:  2020-03-12       Impact factor: 5.310
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.