BACKGROUND: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription. SCOPE OF REVIEW: We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation. MAJOR CONCLUSIONS: Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination. GENERAL SIGNIFICANCE: Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
BACKGROUND:Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription. SCOPE OF REVIEW: We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation. MAJOR CONCLUSIONS: Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination. GENERAL SIGNIFICANCE: Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
Authors: Dylan Valleau; Dustin J Little; Dominika Borek; Tatiana Skarina; Andrew T Quaile; Rosa Di Leo; Scott Houliston; Alexander Lemak; Cheryl H Arrowsmith; Brian K Coombes; Alexei Savchenko Journal: Proc Natl Acad Sci U S A Date: 2018-09-14 Impact factor: 11.205
Authors: Laila El Khattabi; Haiyan Zhao; Jens Kalchschmidt; Natalie Young; Seolkyoung Jung; Peter Van Blerkom; Philippe Kieffer-Kwon; Kyong-Rim Kieffer-Kwon; Solji Park; Xiang Wang; Jordan Krebs; Subhash Tripathi; Noboru Sakabe; Débora R Sobreira; Su-Chen Huang; Suhas S P Rao; Nathanael Pruett; Daniel Chauss; Erica Sadler; Andrea Lopez; Marcelo A Nóbrega; Erez Lieberman Aiden; Francisco J Asturias; Rafael Casellas Journal: Cell Date: 2019-08-08 Impact factor: 41.582