| Literature DB >> 2298289 |
M Yoshida1, T Sakai, N Hosokawa, N Marui, K Matsumoto, A Fujioka, H Nishino, A Aoike.
Abstract
Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the IC50 value was 32-55 microM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 microM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G1 to the S phase.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2298289 DOI： 10.1016/0014-5793(90)80053-l
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124