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Literature DB >> 22981647

Natural deletion of L35Y36 in p6 gag eliminate LYPXnL/ALIX auxiliary virus release pathway in HIV-1 subtype C.

Abstract

Natural loss of L35Y36 residues in ALIX binding site of HIV-1 subtype C was found to prevent the p6 gag-ALIX interaction. Over expression of ALIX 364-716 (V-domain) unlike pNL4.3 (subtype B), also did not inhibit the release of chimeric pNL4.3 expressing subtype C p6 late domain. Loss of V domain binding consequently affected the ALIX mediated particle release in the absence of PTAP/TSG101 pathway. Our data indicated absence of LYPXnL/ALIX pathway in HIV-1 subtype C.

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Year: 2012 PMID： 22981647 DOI： 10.1016/j.virusres.2012.08.020

Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303

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Cited

8 in total

1. CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.

Authors: David O Ajasin; Vasudev R Rao; Xuhong Wu; Santhamani Ramasamy; Mario Pujato; Arthur P Ruiz; Andras Fiser; Anne R Bresnick; Ganjam V Kalpana; Vinayaka R Prasad
Journal: Elife Date: 2019-06-07 Impact factor: 8.140

2. Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.

Authors: Marion W Kiguoya; Jaclyn K Mann; Denis Chopera; Kamini Gounder; Guinevere Q Lee; Peter W Hunt; Jeffrey N Martin; T Blake Ball; Joshua Kimani; Zabrina L Brumme; Mark A Brockman; Thumbi Ndung'u
Journal: J Virol Date: 2017-06-09 Impact factor: 5.103

3. HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness.

Authors: Robert van Domselaar; Duncan T Njenda; Rohit Rao; Anders Sönnerborg; Kamalendra Singh; Ujjwal Neogi
Journal: J Virol Date: 2019-04-17 Impact factor: 5.103

4. Phylogenetic characterization of six full-length HIV-1 subtype C molecular clones from three patients: identification of rare subtype C strains containing two NF-κB motifs in the long terminal repeat.

Authors: Luke Elizabeth Hanna; Ujjwal Neogi; Udaykumar Ranga; Soumya Swaminathan; Vinayaka R Prasad
Journal: AIDS Res Hum Retroviruses Date: 2014-02-07 Impact factor: 2.205

5. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Authors: Ujjwal Neogi; Shwetha D Rao; Irene Bontell; Jens Verheyen; Vasudev R Rao; Sagar C Gore; Neelesh Soni; Anita Shet; Eugen Schülter; Maria L Ekstrand; Amogne Wondwossen; Rolf Kaiser; Mallur S Madhusudhan; Vinayaka R Prasad; Anders Sonnerborg
Journal: AIDS Date: 2014-09-24 Impact factor: 4.177

Natural deletion of L35Y36 in p6 gag eliminate LYPXnL/ALIX auxiliary virus release pathway in HIV-1 subtype C.

1. CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.

2. Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression.

3. HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness.

4. Phylogenetic characterization of six full-length HIV-1 subtype C molecular clones from three patients: identification of rare subtype C strains containing two NF-κB motifs in the long terminal repeat.

5. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Review 6. Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses.

7. PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain.

Review 8. The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.