Literature DB >> 22980973

Diabetic β Cells: To Be or Not To Be?

Sapna Puri1, Matthias Hebrok.   

Abstract

β cell dysfunction with subsequent apoptosis is considered a significant contributor to the development of type 2 diabetes. Emerging data from Talchai et al. suggest β cell dedifferentiation as an alternative mechanism of insulin insufficiency that might be more amenable to intervention in at least a subset of patients.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22980973      PMCID： PMC4692270          DOI： 10.1016/j.cell.2012.08.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.

Authors:  Limor Landsman; Audrey Parent; Matthias Hebrok
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-03       Impact factor: 11.205

2.  Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Authors:  Patrick Collombat; Jacob Hecksher-Sørensen; Jens Krull; Joachim Berger; Dietmar Riedel; Pedro L Herrera; Palle Serup; Ahmed Mansouri
Journal:  J Clin Invest       Date:  2007-04       Impact factor: 14.808

Review 3.  The binary switch that controls the life and death decisions of ER stressed β cells.

Authors:  Christine M Oslowski; Fumihiko Urano
Journal:  Curr Opin Cell Biol       Date:  2010-12-16       Impact factor: 8.382

4.  Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Authors:  Fabrizio Thorel; Virginie Népote; Isabelle Avril; Kenji Kohno; Renaud Desgraz; Simona Chera; Pedro L Herrera
Journal:  Nature       Date:  2010-04-04       Impact factor: 49.962

Review 5.  Regulation of pancreatic beta-cell function by the forkhead protein FoxO1.

Authors:  J Buteau; D Accili
Journal:  Diabetes Obes Metab       Date:  2007-11       Impact factor: 6.577

6.  Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Authors:  Chutima Talchai; Shouhong Xuan; Hua V Lin; Lori Sussel; Domenico Accili
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

Review 7.  Beta-cell failure as a complication of diabetes.

Authors:  K J Chang-Chen; R Mullur; E Bernal-Mizrachi
Journal:  Rev Endocr Metab Disord       Date:  2008-12       Impact factor: 6.514
  7 in total
  10 in total

Review 1.  Beta cell dynamics: beta cell replenishment, beta cell compensation and diabetes.

Authors:  Marlon E Cerf
Journal:  Endocrine       Date:  2013-03-13       Impact factor: 3.633

2.  Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.

Authors:  Zhiyu Wang; Nathaniel W York; Colin G Nichols; Maria S Remedi
Journal:  Cell Metab       Date:  2014-04-17       Impact factor: 27.287

3.  DNA methylation directs functional maturation of pancreatic β cells.

Authors:  Sangeeta Dhawan; Shuen-Ing Tschen; Chun Zeng; Tingxia Guo; Matthias Hebrok; Aleksey Matveyenko; Anil Bhushan
Journal:  J Clin Invest       Date:  2015-06-22       Impact factor: 14.808

4.  Automated assessment of β-cell area and density per islet and patient using TMEM27 and BACE2 immunofluorescence staining in human pancreatic β-cells.

Authors:  Markus P Rechsteiner; Xenofon Floros; Bernhard O Boehm; Lorella Marselli; Piero Marchetti; Markus Stoffel; Holger Moch; Giatgen A Spinas
Journal:  PLoS One       Date:  2014-06-06       Impact factor: 3.240

5.  Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.

Authors:  Tobias Mühling; Johanna Duda; Jochen H Weishaupt; Albert C Ludolph; Birgit Liss
Journal:  Front Cell Neurosci       Date:  2014-11-14       Impact factor: 5.505

6.  Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Authors:  Nicola Jeffery; Sarah Richardson; David Chambers; Noel G Morgan; Lorna W Harries
Journal:  Hum Mol Genet       Date:  2019-08-15       Impact factor: 6.150

Review 7.  Update on the protective molecular pathways improving pancreatic beta-cell dysfunction.

Authors:  Alessandra Puddu; Roberta Sanguineti; François Mach; Franco Dallegri; Giorgio Luciano Viviani; Fabrizio Montecucco
Journal:  Mediators Inflamm       Date:  2013-05-02       Impact factor: 4.711

8.  VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.

Authors:  Sapna Puri; Haruhiko Akiyama; Matthias Hebrok
Journal:  Genes Dev       Date:  2013-12-01       Impact factor: 11.361

Review 9.  Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review.

Authors:  Weiwei Li; Guoqi Yuan; Yuxiang Pan; Cong Wang; Haixia Chen
Journal:  Front Pharmacol       Date:  2017-02-23       Impact factor: 5.810

Review 10.  mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function.

Authors:  Nicole D Moss; Lori Sussel
Journal:  Front Genet       Date:  2020-09-01       Impact factor: 4.599
  10 in total

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