Literature DB >> 22980907

Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading.

Kurt Watson1, Rainelli Koumangoye, Pamela Thompson, Amos M Sakwe, Tina Patel, Siddharth Pratap, Josiah Ochieng.   

Abstract

Our goal in this study was to define the mechanisms by which fetuin-A mediates the adhesion of tumor cells. The data show that in the absence of fetuin-A, detached tumor cells secrete exosomes that contain most of the known exosomal associated proteins but lack the capacity to mediate cellular adhesion. In the presence of fetuin-A, the cells secrete exosomes, which contain, in addition to the other exosomal proteins, fetuin-A, plasminogen and histones. These exosomes mediate adhesion and cell spreading. Plasminogen is a participant in this novel adhesion mechanism. The data suggest that these exosomes play a role in tumor progression.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22980907      PMCID： PMC3455109          DOI： 10.1016/j.febslet.2012.07.071

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  26 in total

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Journal:  Biol Chem       Date:  1999-01       Impact factor: 3.915

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Journal:  Invasion Metastasis       Date:  1997

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Journal:  Cancer Res       Date:  2005-01-15       Impact factor: 12.701

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Journal:  Biochim Biophys Acta       Date:  2004-08-23

Review 6.  Fetuin: its enigmatic property of growth promotion.

Authors:  Z Nie
Journal:  Am J Physiol       Date:  1992-09

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8.  Extrahepatic expression of plasma protein genes during inflammation.

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Journal:  Inflammation       Date:  1991-10       Impact factor: 4.092

9.  Exosome release is regulated by a calcium-dependent mechanism in K562 cells.

Authors:  Ariel Savina; Marcelo Furlán; Michel Vidal; Maria I Colombo
Journal:  J Biol Chem       Date:  2003-03-14       Impact factor: 5.157

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Authors:  D Mazia; G Schatten; W Sale
Journal:  J Cell Biol       Date:  1975-07       Impact factor: 10.539
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  20 in total

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2.  Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B.

Authors:  Pamela D Thompson; Amos Sakwe; Rainelli Koumangoye; Wendell G Yarbrough; Josiah Ochieng; Dana R Marshall
Journal:  Exp Cell Res       Date:  2013-12-12       Impact factor: 3.905

3.  Serum Proteomic Signatures of Male Breast Cancer.

Authors:  Eleni Zografos; Athanasios K Anagnostopoulos; Aggeliki Papadopoulou; Evangelia Legaki; Flora Zagouri; Evangelos Marinos; George T Tsangaris; Maria Gazouli
Journal:  Cancer Genomics Proteomics       Date:  2019 Mar-Apr       Impact factor: 4.069

Review 4.  The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Authors:  Josiah Ochieng; Gladys N Nangami; Olugbemiga Ogunkua; Isabelle R Miousse; Igor Koturbash; Valerie Odero-Marah; Lisa J McCawley; Pratima Nangia-Makker; Nuzhat Ahmed; Yunus Luqmani; Zhenbang Chen; Silvana Papagerakis; Gregory T Wolf; Chenfang Dong; Binhua P Zhou; Dustin G Brown; Anna Maria Colacci; Roslida A Hamid; Chiara Mondello; Jayadev Raju; Elizabeth P Ryan; Jordan Woodrick; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Rabindra Roy; Stefano Forte; Lorenzo Memeo; Hosni K Salem; Amedeo Amedei; Rabeah Al-Temaimi; Fahd Al-Mulla; William H Bisson; Sakina E Eltom
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

5.  Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4.

Authors:  Josiah Ochieng; Gladys Nangami; Amos Sakwe; Tanu Rana; Shalonda Ingram; Jeffrey S Goodwin; Cierra Moye; Philip Lammers; Samuel E Adunyah
Journal:  FEBS Lett       Date:  2018-09-20       Impact factor: 4.124

Review 6.  Extra-nuclear histones: origin, significance and perspectives.

Authors:  Abhilasha Singh; Sudhir Verma; Sharmila Basu Modak; Madan M Chaturvedi; Jogeswar S Purohit
Journal:  Mol Cell Biochem       Date:  2021-11-18       Impact factor: 3.396

7.  Fetuin-A (α2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel.

Authors:  Gladys N Nangami; Kurt Watson; Kitani Parker-Johnson; Kelechi O Okereke; Amos Sakwe; Pamela Thompson; Nanna Frimpong; Josiah Ochieng
Journal:  Biochem Biophys Res Commun       Date:  2013-08-07       Impact factor: 3.575

8.  Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells.

Authors:  Gladys Nangami; Rainelli Koumangoye; J Shawn Goodwin; Amos M Sakwe; Dana Marshall; James Higginbotham; Josiah Ochieng
Journal:  Exp Cell Res       Date:  2014-09-04       Impact factor: 3.905

9.  Proteomic profiling of retinoblastoma by high resolution mass spectrometry.

Authors:  Ravikanth Danda; Kalaivani Ganapathy; Gajanan Sathe; Anil K Madugundu; Sharavan Ramachandran; Uma Maheswari Krishnan; Vikas Khetan; Pukhraj Rishi; T S Keshava Prasad; Akhilesh Pandey; Subramanian Krishnakumar; Harsha Gowda; Sailaja V Elchuri
Journal:  Clin Proteomics       Date:  2016-10-26       Impact factor: 3.988

10.  Fetuin-A (alpha 2HS glycoprotein) modulates growth, motility, invasion, and senescence in high-grade astrocytomas.

Authors:  Gladys N Nangami; Amos M Sakwe; Michael G Izban; Tanu Rana; Philip E Lammers; Portia Thomas; Zhenbang Chen; Josiah Ochieng
Journal:  Cancer Med       Date:  2016-11-23       Impact factor: 4.452
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