| Literature DB >> 26106135 |
Josiah Ochieng1, Gladys N Nangami1, Olugbemiga Ogunkua1, Isabelle R Miousse2, Igor Koturbash2, Valerie Odero-Marah3, Lisa J McCawley4, Pratima Nangia-Makker5, Nuzhat Ahmed6, Yunus Luqmani7, Zhenbang Chen1, Silvana Papagerakis8, Gregory T Wolf8, Chenfang Dong9, Binhua P Zhou9, Dustin G Brown10, Anna Maria Colacci11, Roslida A Hamid12, Chiara Mondello13, Jayadev Raju14, Elizabeth P Ryan10, Jordan Woodrick15, A Ivana Scovassi13, Neetu Singh16, Monica Vaccari11, Rabindra Roy15, Stefano Forte17, Lorenzo Memeo17, Hosni K Salem18, Amedeo Amedei19, Rabeah Al-Temaimi7, Fahd Al-Mulla7, William H Bisson20, Sakina E Eltom1.
Abstract
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of low-dose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial-mesenchymal transition, for example, in these cells are of particular interest in this review. This we hope will lead to the collaboration between scientists who have dedicated their professional life to the study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.Entities:
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Year: 2015 PMID： 26106135 PMCID： PMC4565611 DOI： 10.1093/carcin/bgv034
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944