Literature DB >> 22977532

Overexpression of engulfment and cell motility 1 promotes cell invasion and migration of hepatocellular carcinoma.

Jiarui Jiang1, Guoqing Liu, Xiongying Miao, Songwen Hua, Dewu Zhong.   

Abstract

Engulfment and cell motility 1 (Elmo1) has been linked to the invasive phenotype of glioma cells. The use of Elmo1 inhibitors is currently being evaluated in hepato-cellular carcinoma (HCC), but the molecular mechanisms of their therapeutic effect have yet to be determined. Elmo1 expression in HCC tissue samples from 131 cases and in 5 HCC cell lines was determined by immunohistochemistry, quantitative RT-PCR and Western blotting. To functionally characterize Elmo1 in HCC, Elmo1 expression in the HCCLM3 cell line was blocked by siRNA. Cell migration was measured by wound healing and transwell migration assays in vitro. Elmo1 overexpression was significantly correlated with cell invasion and the poor prognosis of HCC. Elmo1-siRNA-treated HCCLM3 cells demonstrated a reduction in cell migration. The present study demonstrated for the first time that the suppression of Elmo1 expression inhibits cell invasion in HCC.

Entities:  

Year:  2011        PMID： 22977532      PMCID： PMC3440741          DOI： 10.3892/etm.2011.229

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  28 in total

1.  ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.

Authors:  Michael J Jarzynka; Bo Hu; Kwok-Min Hui; Ifat Bar-Joseph; Weisong Gu; Takanori Hirose; Lisa B Haney; Kodi S Ravichandran; Ryo Nishikawa; Shi-Yuan Cheng
Journal:  Cancer Res       Date:  2007-08-01       Impact factor: 12.701

2.  Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.

Authors:  Kiyo Hiramoto; Manabu Negishi; Hironori Katoh
Journal:  Exp Cell Res       Date:  2006-09-16       Impact factor: 3.905

3.  The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth.

Authors:  Hannah Hope; Christian Schmauch; Robert A Arkowitz; Martine Bassilana
Journal:  Mol Microbiol       Date:  2010-04-27       Impact factor: 3.501

4.  ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs.

Authors:  A Shimazaki; Y Tanaka; T Shinosaki; M Ikeda; H Watada; T Hirose; R Kawamori; S Maeda
Journal:  Kidney Int       Date:  2006-10-04       Impact factor: 10.612

5.  Mortality by cause for eight regions of the world: Global Burden of Disease Study.

Authors:  C J Murray; A D Lopez
Journal:  Lancet       Date:  1997-05-03       Impact factor: 79.321

6.  Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo.

Authors:  Sheng-Zhou Zhang; Fei-Yan Pan; Jian-Feng Xu; Jun Yuan; Shi-Ying Guo; Gu Dai; Bin Xue; Wei-Gan Shen; Chuan-Jun Wen; Dong-Hong Zhao; Chao-Jun Li
Journal:  Mol Cancer Ther       Date:  2005-10       Impact factor: 6.261

7.  Identification of PEG10 as a progression related biomarker for hepatocellular carcinoma.

Authors:  Wai-Ki Ip; Paul B-S Lai; Navy L-Y Wong; Shirley M-H Sy; Ben Beheshti; Jeremy A Squire; Nathalie Wong
Journal:  Cancer Lett       Date:  2006-11-28       Impact factor: 8.679

8.  Risk factors for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma.

Authors:  Salleh Ibrahim; Anupama Roychowdhury; Tay Khoon Hean
Journal:  Am J Surg       Date:  2007-07       Impact factor: 2.565

9.  The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.

Authors:  Tristan Bouschet; Stéphane Martin; Venkateswarlu Kanamarlapudi; Stuart Mundell; Jeremy M Henley
Journal:  J Cell Sci       Date:  2007-07-10       Impact factor: 5.285

10.  Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.

Authors:  Carmen Chak-Lui Wong; Chun-Ming Wong; Frankie Chi-Fat Ko; Lo-Kong Chan; Yick-Pang Ching; Judy Wai-Ping Yam; Irene Oi-lin Ng
Journal:  PLoS One       Date:  2008-07-23       Impact factor: 3.240
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  7 in total

1.  Engulfment and cell motility 1 promotes tumor progression via the modulation of tumor cell survival in gastric cancer.

Authors:  Young-Lan Park; Jung-Ho Choi; Sun-Young Park; Hyung-Hoon Oh; Dong-Ho Kim; Yoon-Jin Seo; Jae-Kyoung So; Kaeun Song; Min-Seok Cho; Min-Woo Chung; Ji-Yun Hong; Ki-Hyun Kim; Eun Myung; Dae-Seong Myung; Sung-Bum Cho; Wan-Sik Lee; Daeho Park; Young-Eun Joo
Journal:  Am J Transl Res       Date:  2020-12-15       Impact factor: 4.060

Review 2.  Role of ELMO1 in inflammation and cancer-clinical implications.

Authors:  Stefania Tocci; Stella-Rita Ibeawuchi; Soumita Das; Ibrahim M Sayed
Journal:  Cell Oncol (Dordr)       Date:  2022-06-06       Impact factor: 7.051

3.  Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure.

Authors:  Scott S Auerbach; Miaofei Xu; B Alex Merrick; Mark J Hoenerhoff; Dhiral Phadke; Debra J Taxman; Ruchir Shah; Hue-Hua L Hong; Thai-Vu Ton; Ramesh C Kovi; Robert C Sills; Arun R Pandiri
Journal:  Toxicol Pathol       Date:  2018-07-25       Impact factor: 1.902

4.  Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer.

Authors:  Hui-Yun Peng; Qiong-Fang Yu; Wei Shen; Cheng-Ming Guo; Zhen Li; Xiao-Yan Zhou; Nan-Jin Zhou; Wei-Ping Min; Dian Gao
Journal:  Int J Mol Sci       Date:  2016-12-16       Impact factor: 5.923

5.  De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones.

Authors:  Heather A McCauley; Véronique Chevrier; Daniel Birnbaum; Géraldine Guasch
Journal:  Elife       Date:  2017-02-21       Impact factor: 8.140

6.  Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish.

Authors:  Rongtao Xue; Ying Wang; Tienan Wang; Mei Lyu; Guiling Mo; Xijie Fan; Jianchao Li; Kuangyu Yen; Shihui Yu; Qifa Liu; Jin Xu
Journal:  Front Cell Dev Biol       Date:  2021-12-21

7.  ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis.

Authors:  Yecheng Wang; Hongyan Li; Fei Li
Journal:  PeerJ       Date:  2020-04-06       Impact factor: 2.984
  7 in total

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