Literature DB >> 2297680

Double minute chromosomes in the leukocytes of a young girl with breast carcinoma.

R Madhavi1, M Guntur, R Ghosh, P K Ghosh.   

Abstract

Cytogenetic analysis was performed in a young girl with breast carcinoma. The most important finding was the existence of double minute (dmin) chromosomes, besides other chromosomal abnormalities. Removal of the tumor resulted in reduction of chromosomal abnormalities in the leukocyte cultures repeated after 1 year, suggesting that the presence of tumor may elevate the frequency of chromosomal abnormalities. The presence of dmin chromosomes indicates that factors causing their presence in tumor cells may also operate in human leukocytes.

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Year:  1990        PMID： 2297680     DOI： 10.1016/0165-4608(90)90048-f

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  4 in total

1.  Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients.

Authors:  V Balachandar; B Lakshman Kumar; K Sasikala; P Manikantan; R Sangeetha; S Mohana Devi
Journal:  J Zhejiang Univ Sci B       Date:  2007-09       Impact factor: 3.066

2.  Chromosomal instability in breast cancer patients.

Authors:  L Barrios; M R Caballín; R Miró; C Fuster; F Guedea; A Subias; J Egozcue
Journal:  Hum Genet       Date:  1991-11       Impact factor: 4.132

3.  Identification of the origin of double minutes in normal human cells by laser-based chromosome microdissection approach.

Authors:  E Rajcan-Separovic; H S Wang; M D Speevak; L Janes; R G Korneluk; K Wakasa; J E Ikeda
Journal:  Hum Genet       Date:  1995-07       Impact factor: 4.132

4.  Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients.

Authors:  Andrea Hille; Hana Hofman-Hüther; Elna Kühnle; Barbara Wilken; Margret Rave-Fränk; Heinz Schmidberger; Patricia Virsik
Journal:  Radiat Environ Biophys       Date:  2009-09-18       Impact factor: 1.925
  4 in total

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