PURPOSE: We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program. METHODS: European-derived American volunteers (men=111, women=131, 23.4 ± 5.4 yr, 24.4 ± 4.6 kg·m(-2)) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A>G (rs1137100), 668 A>G (rs1137101), 3057 G>A (rs1805096), and 1968 G>C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12 wk of supervised RT with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates. RESULTS: Adults with the LEP 19 GG genotype reported more kcal/wk in vigorous intensity PA (1273.3 ± 176.8, p=0.017) and sports/recreation (1922.8 ± 226.0, p<0.04) than A allele carriers (718.0 ± 147.2, 1328.6 ± 188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7 ± 1.6) than A allele carriers (35.0 ± 1.4, p=0.03). In response to RT, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05 ± 3186.7 vs. 52,321.87 ± 5125.05 mm(3), p=0.01) and subcutaneous fat volume (10,599.89 ± 3683.57 vs. -5224.73 ± 5923.98 mm(3), p=0.02) than adults with the LEPR 668 AA genotype, respectively. CONCLUSION: LEP19 G>A and LEPR 668 A>G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed.
PURPOSE: We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program. METHODS: European-derived American volunteers (men=111, women=131, 23.4 ± 5.4 yr, 24.4 ± 4.6 kg·m(-2)) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A>G (rs1137100), 668 A>G (rs1137101), 3057 G>A (rs1805096), and 1968 G>C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12 wk of supervised RT with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates. RESULTS: Adults with the LEP 19 GG genotype reported more kcal/wk in vigorous intensity PA (1273.3 ± 176.8, p=0.017) and sports/recreation (1922.8 ± 226.0, p<0.04) than A allele carriers (718.0 ± 147.2, 1328.6 ± 188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7 ± 1.6) than A allele carriers (35.0 ± 1.4, p=0.03). In response to RT, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05 ± 3186.7 vs. 52,321.87 ± 5125.05 mm(3), p=0.01) and subcutaneous fat volume (10,599.89 ± 3683.57 vs. -5224.73 ± 5923.98 mm(3), p=0.02) than adults with the LEPR 668 AA genotype, respectively. CONCLUSION: LEP19 G>A and LEPR 668 A>G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed.
Authors: William L Haskell; I-Min Lee; Russell R Pate; Kenneth E Powell; Steven N Blair; Barry A Franklin; Caroline A Macera; Gregory W Heath; Paul D Thompson; Adrian Bauman Journal: Med Sci Sports Exerc Date: 2007-08 Impact factor: 5.411
Authors: Sean Walsh; Bethany K Kelsey; Theodore J Angelopoulos; Priscilla M Clarkson; Paul M Gordon; Niall M Moyna; Paul S Visich; Robert F Zoeller; Richard L Seip; Steve Bilbie; Paul D Thompson; Eric P Hoffman; Thomas B Price; Joseph M Devaney; Linda S Pescatello Journal: J Appl Physiol (1985) Date: 2009-07-23
Authors: Funda E Orkunoglu-Suer; Brennan T Harmon; Heather Gordish-Dressman; Priscilla M Clarkson; Paul D Thompson; Theodore J Angelopoulos; Paul M Gordon; Monica J Hubal; Niall M Moyna; Linda S Pescatello; Paul S Visich; Robert F Zoeller; Eric P Hoffman; Joseph M Devaney Journal: Obesity (Silver Spring) Date: 2010-08-19 Impact factor: 5.002
Authors: Julieta Uthurralt; Heather Gordish-Dressman; Meg Bradbury; Carolina Tesi-Rocha; Joseph Devaney; Brennan Harmon; Erica K Reeves; Cinzia Brandoli; Barbara C Hansen; Richard L Seip; Paul D Thompson; Thomas B Price; Theodore J Angelopoulos; Priscilla M Clarkson; Niall M Moyna; Linda S Pescatello; Paul S Visich; Robert F Zoeller; Paul M Gordon; Eric P Hoffman Journal: BMC Med Genet Date: 2007-08-16 Impact factor: 2.103
Authors: Benjamin C Dexter; Kamal Rahmouni; Taylor Cushman; Gregory M Hermann; Charles Ni; Peg C Nopoulos; Daniel L Thedens; Robert D Roghair Journal: Behav Brain Res Date: 2014-01-25 Impact factor: 3.332
Authors: Juha P Ahtiainen; Simon Walker; Heikki Peltonen; Jarkko Holviala; Elina Sillanpää; Laura Karavirta; Janne Sallinen; Jussi Mikkola; Heli Valkeinen; Antti Mero; Juha J Hulmi; Keijo Häkkinen Journal: Age (Dordr) Date: 2016-01-15
Authors: N R Harvey; S Voisin; P J Dunn; H Sutherland; X Yan; M Jacques; I D Papadimitriou; L J Haseler; K J Ashton; L M Haupt; N Eynon; L R Griffiths Journal: Mol Genet Genomics Date: 2020-01-02 Impact factor: 3.291
Authors: Christopher G Vann; Robert W Morton; Christopher B Mobley; Ivan J Vechetti; Brian K Ferguson; Cody T Haun; Shelby C Osburn; Casey L Sexton; Carlton D Fox; Matthew A Romero; Paul A Roberson; Sara Y Oikawa; Chris McGlory; Kaelin C Young; John J McCarthy; Stuart M Phillips; Michael D Roberts Journal: FASEB J Date: 2021-05 Impact factor: 5.191
Authors: Linda S Pescatello; Joseph M Devaney; Monica J Hubal; Paul D Thompson; Eric P Hoffman Journal: Biomed Res Int Date: 2013-12-23 Impact factor: 3.411
Authors: Joaquín Sanchis-Moysi; José Antonio Serrano-Sánchez; Juan José González-Henríquez; José A L Calbet; Cecilia Dorado Journal: Front Pediatr Date: 2019-08-20 Impact factor: 3.418