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Literature DB >> 22972672

Considerations for measuring iron in post-mortem tissue of Parkinson's disease patients.

Dominic J Hare¹, Manfred Gerlach, Peter Riederer.

Abstract

Redox-active iron is considered to be an important factor in the pathology and progression of several neurodegenerative disorders, including Parkinson's disease. The various roles of iron in normal physiology and its prevalence in the wider environment present numerous challenges to both accurate measurement and interpretation of brain iron levels. This review will discuss considerations for the analysis of iron in post-mortem samples, including how contamination, sample preparation and methods of analysis may influence results. In addition, several important factors influencing interpretation of iron levels will be considered.

Entities: Chemical Disease Species

Mesh：

Substances：
Iron

Year: 2012 PMID： 22972672 DOI： 10.1007/s00702-012-0898-4

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

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