Literature DB >> 22969053

Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.

Kui Cheng1, Xiaohui Wang, Shuting Zhang, Hang Yin.   

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Year:  2012        PMID： 22969053      PMCID： PMC3510333          DOI： 10.1002/anie.201204910

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  26 in total

1.  Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities.

Authors:  Shengmin Sang; Joshua D Lambert; Shiying Tian; Jungil Hong; Zhe Hou; Jae-He Ryu; Ruth E Stark; Robert T Rosen; Mou-Tuan Huang; Chung S Yang; Chi-Tang Ho
Journal:  Bioorg Med Chem       Date:  2004-01-15       Impact factor: 3.641

2.  Toll signaling: the TIReless quest for specificity.

Authors:  Jean-Luc Imler; Jules A Hoffmann
Journal:  Nat Immunol       Date:  2003-02       Impact factor: 25.606

3.  Simultaneously monitoring DNA binding and helicase-catalyzed DNA unwinding by fluorescence polarization.

Authors:  H Q Xu; A H Zhang; C Auclair; X G Xi
Journal:  Nucleic Acids Res       Date:  2003-07-15       Impact factor: 16.971

4.  Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Authors:  Shinichi Kitada; Marilisa Leone; Sina Sareth; Dayong Zhai; John C Reed; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2003-09-25       Impact factor: 7.446

Review 5.  Accessory molecules for Toll-like receptors and their function.

Authors:  Clarissa C Lee; Ana M Avalos; Hidde L Ploegh
Journal:  Nat Rev Immunol       Date:  2012-02-03       Impact factor: 53.106

Review 6.  Pathogen recognition and innate immunity.

Authors:  Shizuo Akira; Satoshi Uematsu; Osamu Takeuchi
Journal:  Cell       Date:  2006-02-24       Impact factor: 41.582

7.  Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.

Authors:  O Takeuchi; K Hoshino; S Akira
Journal:  J Immunol       Date:  2000-11-15       Impact factor: 5.422

8.  Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.

Authors:  Evelyn A Kurt-Jones; Melvin Chan; Shenghua Zhou; Jennifer Wang; George Reed; Roderick Bronson; Michelle M Arnold; David M Knipe; Robert W Finberg
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-22       Impact factor: 11.205

9.  Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.

Authors:  Marilisa Leone; Dayong Zhai; Sina Sareth; Shinichi Kitada; John C Reed; Maurizio Pellecchia
Journal:  Cancer Res       Date:  2003-12-01       Impact factor: 12.701

10.  Molecular structure and antioxidant specificity of purpurogallin in three types of human cardiovascular cells.

Authors:  T W Wu; L H Zeng; J Wu; K P Fung; R D Weisel; A Hempel; N Camerman
Journal:  Biochem Pharmacol       Date:  1996-10-11       Impact factor: 5.858
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  34 in total

1.  Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.

Authors:  Pragnesh Mistry; Michelle H W Laird; Ryan S Schwarz; Shannon Greene; Tristan Dyson; Greg A Snyder; Tsan Sam Xiao; Jay Chauhan; Steven Fletcher; Vladimir Y Toshchakov; Alexander D MacKerell; Stefanie N Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 2.  Targeting protein-protein interfaces using macrocyclic peptides.

Authors:  Meng Gao; Kui Cheng; Hang Yin
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

3.  Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice.

Authors:  Young Rae Ji; Hei Jung Kim; Ki Beom Bae; Sanggyu Lee; Myoung Ok Kim; Zae Young Ryoo
Journal:  J Biol Chem       Date:  2015-04-06       Impact factor: 5.157

4.  Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response.

Authors:  Meng Gao; Nir London; Kui Cheng; Ryo Tamura; Jialin Jin; Ora Schueler-Furman; Hang Yin
Journal:  Tetrahedron       Date:  2014-10-21       Impact factor: 2.457

5.  Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.

Authors:  Clara Westwell-Roper; Heather C Denroche; Jan A Ehses; C Bruce Verchere
Journal:  J Biol Chem       Date:  2016-01-19       Impact factor: 5.157

6.  Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.

Authors:  Stefano G Daniele; Dawn Béraud; Connor Davenport; Kui Cheng; Hang Yin; Kathleen A Maguire-Zeiss
Journal:  Sci Signal       Date:  2015-05-12       Impact factor: 8.192

7.  Amantadine attenuates sepsis-induced cognitive dysfunction possibly not through inhibiting toll-like receptor 2.

Authors:  Wei Xing; Pinjie Huang; Yang Lu; Weian Zeng; Zhiyi Zuo
Journal:  J Mol Med (Berl)       Date:  2018-03-03       Impact factor: 4.599

8.  Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells.

Authors:  Zong-Mei Bian; Matthew G Field; Susan G Elner; Victor M Elner
Journal:  Exp Eye Res       Date:  2018-03-15       Impact factor: 3.467

9.  Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.

Authors:  Yohance M Allette; Michael R Due; Sarah M Wilson; Polina Feldman; Matthew S Ripsch; Rajesh Khanna; Fletcher A White
Journal:  Brain Behav Immun       Date:  2014-07-08       Impact factor: 7.217

Review 10.  Targeting Toll-like receptors with small molecule agents.

Authors:  Xiaohui Wang; Christina Smith; Hang Yin
Journal:  Chem Soc Rev       Date:  2013-06-21       Impact factor: 54.564
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