BACKGROUND AND PURPOSE: Several studies have reported that obese patients have a higher risk of nephrolithiasis. The purpose of this study is to investigate the effect of overweight (OW) and obesity on stone composition, type of treatment, and urine composition. METHODS: With Institutional Review Board approval, charts of adult patients who attended our dedicated stone clinic over a 5-year period starting January 2006 were reviewed. Patients were categorized into normal (body mass index 18.5-24.9), OW (25-29.9), and obese (≥30). We excluded those who did not have at least one 24-hour urine analysis. RESULTS: OW and obese patients were more likely to have previous stones, more chance to have uric acid stones, and to be treated with shockwave lithotripsy in the community, and with ureteroscopy or percutaneous nephrolithotripsy in our center. They needed more thiazide diuretics, allopurinol, and dietitian counseling. They had statistically significant (P<0.05) higher urine calcium, citrate, supersaturation calcium phosphate, uric acid, supersaturation uric acid, sodium, potassium, magnesium, phosphorus, chloride, sulfate, urine urea nitrogen, protein catabolic rate, and creatinine compared with those with normal weight. CONCLUSION: OW and obese patients have different stone composition with increased excretion of stone promoters in the urine. Stone prevention measures should be introduced during metabolic syndrome evaluation.
BACKGROUND AND PURPOSE: Several studies have reported that obesepatients have a higher risk of nephrolithiasis. The purpose of this study is to investigate the effect of overweight (OW) and obesity on stone composition, type of treatment, and urine composition. METHODS: With Institutional Review Board approval, charts of adult patients who attended our dedicated stone clinic over a 5-year period starting January 2006 were reviewed. Patients were categorized into normal (body mass index 18.5-24.9), OW (25-29.9), and obese (≥30). We excluded those who did not have at least one 24-hour urine analysis. RESULTS: OW and obesepatients were more likely to have previous stones, more chance to have uric acid stones, and to be treated with shockwave lithotripsy in the community, and with ureteroscopy or percutaneous nephrolithotripsy in our center. They needed more thiazide diuretics, allopurinol, and dietitian counseling. They had statistically significant (P<0.05) higher urine calcium, citrate, supersaturation calcium phosphate, uric acid, supersaturation uric acid, sodium, potassium, magnesium, phosphorus, chloride, sulfate, urine ureanitrogen, protein catabolic rate, and creatinine compared with those with normal weight. CONCLUSION: OW and obesepatients have different stone composition with increased excretion of stone promoters in the urine. Stone prevention measures should be introduced during metabolic syndrome evaluation.
Authors: Hien Tran; Jacob S Grange; Beverley Adams-Huet; Fiemu E Nwariaku; Jennifer L Rabaglia; Stacey L Woodruff; Shelby A Holt; Naim M Maalouf Journal: J Clin Endocrinol Metab Date: 2014-03-31 Impact factor: 5.958
Authors: Xiangling Wang; Amy E Krambeck; James C Williams; Xiaojing Tang; Andrew D Rule; Fang Zhao; Eric Bergstralh; Zejfa Haskic; Samuel Edeh; David R Holmes; Loren P Herrera Hernandez; John C Lieske Journal: Clin J Am Soc Nephrol Date: 2014-08-04 Impact factor: 8.237
Authors: Abdülmuttalip Şimşek; Faruk Özgör; Mehmet Fatih Akbulut; Onur Küçüktopçu; Ahmet Yalçın Berberoğlu; Ömer Sarılar; Murat Binbay; Ahmet Yaser Müslümanoğlu Journal: Turk J Urol Date: 2014-06
Authors: Mathieu V Paulin; Marilyn Dunn; Catherine Vachon; Guy Beauchamp; Bérénice Conversy Journal: J Vet Intern Med Date: 2021-12-02 Impact factor: 3.333
Authors: Fabio Cesar Miranda Torricelli; Robert Brown; Fernanda C G Berto; Sarah Tarplin; Miguel Srougi; Eduardo Mazzucchi; Manoj Monga Journal: Can Urol Assoc J Date: 2015 Mar-Apr Impact factor: 1.862
Authors: Catherine M Bulka; Sithembile L Mabila; James P Lash; Mary E Turyk; Maria Argos Journal: Environ Health Perspect Date: 2017-08-28 Impact factor: 9.031