Tuo Deng1,2,3, Zanlin Mai1,2,3, Xiaolu Duan1,2,3, Zhijian Zhao1,2,3, Wei Zhu1,2,3, Chao Cai1,2,3, Wenqi Wu1,2,3, Guohua Zeng4,5,6. 1. Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road 1#, Haizhu District, Guangzhou, 510230, Guangdong, China. 2. Guangzhou Institute of Urology, Guangzhou, China. 3. Guangdong Key Laboratory of Urology, Guangdong, China. 4. Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangda Road 1#, Haizhu District, Guangzhou, 510230, Guangdong, China. gzgyzgh@vip.tom.com. 5. Guangzhou Institute of Urology, Guangzhou, China. gzgyzgh@vip.tom.com. 6. Guangdong Key Laboratory of Urology, Guangdong, China. gzgyzgh@vip.tom.com.
Abstract
PURPOSE: To explore the association between hypertension and 24-h urine composition in adults without urolithiasis in China. MATERIALS AND METHODS: Blood test and 24-h urine analysis were performed on 958 non-stone formers in six cities to select eligible participants. Eligible participants were divided into hypertension group and non-hypertension group according to WHO guidelines. The 24-h urine compositions between two groups were compared using univariate and multivariate logistic regressions. RESULTS: A total of 584 adults without urolithiasis were included in this analysis. Compared with non-hypertension group, hypertension group had significantly older age, higher BMI, higher prevalence of diabetes mellitus and higher levels of total cholesterol and LDL, but lower eCCr value, lower levels of serum creatinine and serum sodium (all P value < 0.05). In univariable comparisons, hypertension patients had significantly higher level of urine potassium (mean difference [MD] = - 3.89 mmol, 95% confidence interval [CI] - 7.37 to - 0.42, P = 0.014) but lower levels of urine creatinine (MD = 0.80 mmol, 95% CI 0.21-1.39, P = 0.004) and pH (MD = 0.12, 95% CI - 0.01 to 0.25, P = 0.033) than non-hypertension adults. However, no significant difference was found in all 24-h urinary components between two groups (all P value > 0.05) in multivariate Logistic regression analyses. CONCLUSIONS: Our study demonstrated that hypertension did not independently influence the 24-h urine composition in adults without urolithiasis in China; however, we cannot make such an arbitrary conclusion that hypertension was not a risk factor for urolithiasis.
PURPOSE: To explore the association between hypertension and 24-h urine composition in adults without urolithiasis in China. MATERIALS AND METHODS: Blood test and 24-h urine analysis were performed on 958 non-stone formers in six cities to select eligible participants. Eligible participants were divided into hypertension group and non-hypertension group according to WHO guidelines. The 24-h urine compositions between two groups were compared using univariate and multivariate logistic regressions. RESULTS: A total of 584 adults without urolithiasis were included in this analysis. Compared with non-hypertension group, hypertension group had significantly older age, higher BMI, higher prevalence of diabetes mellitus and higher levels of total cholesterol and LDL, but lower eCCr value, lower levels of serum creatinine and serum sodium (all P value < 0.05). In univariable comparisons, hypertensionpatients had significantly higher level of urine potassium (mean difference [MD] = - 3.89 mmol, 95% confidence interval [CI] - 7.37 to - 0.42, P = 0.014) but lower levels of urine creatinine (MD = 0.80 mmol, 95% CI 0.21-1.39, P = 0.004) and pH (MD = 0.12, 95% CI - 0.01 to 0.25, P = 0.033) than non-hypertension adults. However, no significant difference was found in all 24-h urinary components between two groups (all P value > 0.05) in multivariate Logistic regression analyses. CONCLUSIONS: Our study demonstrated that hypertension did not independently influence the 24-h urine composition in adults without urolithiasis in China; however, we cannot make such an arbitrary conclusion that hypertension was not a risk factor for urolithiasis.
Authors: Andreas Skolarikos; Michael Straub; Thomas Knoll; Kemal Sarica; Christian Seitz; Ales Petřík; Christian Türk Journal: Eur Urol Date: 2014-11-20 Impact factor: 20.096
Authors: Christopher Hartman; Justin I Friedlander; Daniel M Moreira; David A Leavitt; David M Hoenig; Arthur D Smith; Zeph Okeke Journal: Urology Date: 2015-03 Impact factor: 2.649
Authors: Christopher Hartman; Justin I Friedlander; Daniel M Moreira; Sammy E Elsamra; Arthur D Smith; Zeph Okeke Journal: BJU Int Date: 2014-08-13 Impact factor: 5.588
Authors: R Todd Alexander; Brenda R Hemmelgarn; Natasha Wiebe; Aminu Bello; Catherine Morgan; Susan Samuel; Scott W Klarenbach; Gary C Curhan; Marcello Tonelli Journal: BMJ Date: 2012-08-29