| Literature DB >> 22963763 |
Peng Zhu1, Hanjing Peng, Nanting Ni, Binghe Wang, Minyong Li.
Abstract
In this letter, a high-throughput virtual screening was accomplished to identify potent inhibitors against AI-2 quorum sensing on the basis of Vibrio harveyi LuxPQ crystal structure. Seven compounds were found to inhibit AI-2 quorum sensing with IC(50) values in the micromolar range, and presented low cytotoxicity or no cytotoxicity in V. harveyi.Entities:
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Year: 2012 PMID： 22963763 DOI： 10.1016/j.bmcl.2012.08.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823