Junping Zhong1, Sihua Yang, Xiaohui Zheng, Ting Zhou, Da Xing. 1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Abstract
AIM: The objective of this work was to study the photoacoustic effect of a special nanoparticle for selective cancer cell killing both in vitro and in vivo. MATERIALS & METHODS: The nanoparticles (NPs) consisting of indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) and folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with the ICG-PL-PEG-FA solution were exposed to laser pulses. Finally, tumors in mice were treated with photoacoustic technique. RESULTS: High selectivity of the photoacoustic destruction of cancer cells was observed. The tumors in mice after photoacoustic treatment showed a much slower growth rate. CONCLUSION: The destruction of the cells was due to the photoacoustic effect originating from the NPs. The ICG-PL-PEG NP-based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.
AIM: The objective of this work was to study the photoacoustic effect of a special nanoparticle for selective cancer cell killing both in vitro and in vivo. MATERIALS & METHODS: The nanoparticles (NPs) consisting of indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) and folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with the ICG-PL-PEG-FA solution were exposed to laser pulses. Finally, tumors in mice were treated with photoacoustic technique. RESULTS: High selectivity of the photoacoustic destruction of cancer cells was observed. The tumors in mice after photoacoustic treatment showed a much slower growth rate. CONCLUSION: The destruction of the cells was due to the photoacoustic effect originating from the NPs. The ICG-PL-PEG NP-based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.