Literature DB >> 22961758

High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species.

Sigalit Meker1, Katrin Margulis-Goshen, Ester Weiss, Shlomo Magdassi, Edit Y Tshuva.   

Abstract

A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV) complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV) can provide high cytotoxicity with controlled biological function.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22961758     DOI： 10.1002/anie.201205973

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  10 in total

1.  Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents.

Authors:  Isabel de la Cueva-Alique; Laura Muñoz-Moreno; Yosra Benabdelouahab; Benelita T Elie; Mohammed Amin El Amrani; Marta E G Mosquera; María Contel; Ana M Bajo; Tomás Cuenca; Eva Royo
Journal:  J Inorg Biochem       Date:  2015-12-09       Impact factor: 4.155

2.  Anticancer metal complexes: synthesis and cytotoxicity evaluation by the MTT assay.

Authors:  Nitzan Ganot; Sigalit Meker; Lilia Reytman; Avia Tzubery; Edit Y Tshuva
Journal:  J Vis Exp       Date:  2013-11-10       Impact factor: 1.355

3.  Synthesis, spectral and extended spectrum beta-lactamase studies of transition metal tetraaza macrocyclic complexes.

Authors:  Dinesh Kumar; Nutan Sharma; Manjula Nair
Journal:  J Biol Inorg Chem       Date:  2017-01-18       Impact factor: 3.358

4.  Active curcumin nanoparticles formed from a volatile microemulsion template.

Authors:  K Margulis; S Srinivasan; M J Ware; H D Summers; B Godin; S Magdassi
Journal:  J Mater Chem B       Date:  2014       Impact factor: 6.331

5.  Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C1-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds.

Authors:  Gilad Nahari; Edit Y Tshuva
Journal:  Dalton Trans       Date:  2021-05-04       Impact factor: 4.390

6.  Synthesis of Pure Enantiomers of Titanium(IV) Complexes with Chiral Diaminobis(phenolato) Ligands and Their Biological Reactivity.

Authors:  Maya Miller; Edit Y Tshuva
Journal:  Sci Rep       Date:  2018-06-26       Impact factor: 4.379

7.  Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug.

Authors:  Maya Miller; Anna Mellul; Maya Braun; Dana Sherill-Rofe; Emiliano Cohen; Zohar Shpilt; Irene Unterman; Ori Braitbard; Jacob Hochman; Edit Y Tshuva; Yuval Tabach
Journal:  iScience       Date:  2020-06-12

8.  Biomolecular Interaction, Anti-Cancer and Anti-Angiogenic Properties of Cobalt(III) Schiff Base Complexes.

Authors:  Subramanian Ambika; Yesaiyan Manojkumar; Sankaralingam Arunachalam; Balakrishnan Gowdhami; Kishore Kumar Meenakshi Sundaram; Rajadurai Vijay Solomon; Ponnambalam Venuvanalingam; Mohammad Abdulkader Akbarsha; Muthuraman Sundararaman
Journal:  Sci Rep       Date:  2019-02-25       Impact factor: 4.379

9.  Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines.

Authors:  Maya Miller; Edit Y Tshuva
Journal:  RSC Adv       Date:  2018-11-27       Impact factor: 4.036

10.  In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs.

Authors:  Nitzan Ganot; Ori Briaitbard; Asaad Gammal; Joseph Tam; Jacob Hochman; Edit Y Tshuva
Journal:  ChemMedChem       Date:  2018-10-19       Impact factor: 3.466
  10 in total

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