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Literature DB >> 22960761

Post-transcriptional control of miRNA abundance in Arabidopsis.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs (small RNAs) that are 20-24nt in length and predominantly repress gene expression at post-transcriptional levels. They regulate many biological processes including development, metabolism and physiology. Numerous studies have revealed that the steady-state levels of miRNA are under sophisticated control to ensure their proper function. In this review, we summarize recent advances on regulation of miRNA processing and stability in plants.

Entities: Species

Keywords: Arabidopsis; miRNA abundance; miRNA stability; post-transcriptional regulation; pri-miRNA processing

Mesh：

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Year: 2012 PMID： 22960761 PMCID： PMC3548868 DOI： 10.4161/psb.21956

Source DB: PubMed Journal: Plant Signal Behav ISSN： 1559-2316

55 in total

Post-transcriptional control of miRNA abundance in Arabidopsis.

1. MicroRNA genes are transcribed by RNA polymerase II.

2. Biochemical specialization within Arabidopsis RNA silencing pathways.

3. Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.

4. The evolutionarily conserved TOUGH protein is required for proper development of Arabidopsis thaliana.

5. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA.

6. Multiple distinct small RNAs originate from the same microRNA precursors.

7. Negative feedback regulation of Dicer-Like1 in Arabidopsis by microRNA-guided mRNA degradation.

8. The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.

9. Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis.

10. CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana.

1. MiR-107 suppresses cell proliferation and tube formation of Ewing sarcoma cells partly by targeting HIF-1β.

Review 2. microRNA biogenesis, degradation and activity in plants.

3. Functional intron-derived miRNAs and host-gene expression in plants.