OBJECTIVES: The objective of this report is to evaluate functioning in bipolar disorder in a population-based sample of young adults (18 to 24 years old). To this end, people with bipolar disorder were compared with matched participants with only depressive episodes and control subjects without a history of mood episodes. METHODS: Case-control study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. The Functioning Assessment Short Test was used as a measure of general functioning. A multivariate model was elaborated to account for potential confounders. RESULTS: The sample consisted of 231 subjects. Both bipolar disorder (coef=0.60, SE=0.14, p<0.001) and major depression (coef=0.44, SE=0.14, p=0.001) were associated with functioning in the multivariate model. Current depressive symptoms appeared to influence functioning in those with major depression (Z=2.05, p=0.04), but not in those with bipolar disorder (Z=0.78, p=0.43). LIMITATION: Neuropsychological testing was not performed and we see it as an important limitation of this study. CONCLUSION: This population-based study further reinforces the notion that functional impairment is a fundamental characteristic of bipolar illness. It is present from early stages and is not completely explained by mood symptoms.
OBJECTIVES: The objective of this report is to evaluate functioning in bipolar disorder in a population-based sample of young adults (18 to 24 years old). To this end, people with bipolar disorder were compared with matched participants with only depressive episodes and control subjects without a history of mood episodes. METHODS: Case-control study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. The Functioning Assessment Short Test was used as a measure of general functioning. A multivariate model was elaborated to account for potential confounders. RESULTS: The sample consisted of 231 subjects. Both bipolar disorder (coef=0.60, SE=0.14, p<0.001) and major depression (coef=0.44, SE=0.14, p=0.001) were associated with functioning in the multivariate model. Current depressive symptoms appeared to influence functioning in those with major depression (Z=2.05, p=0.04), but not in those with bipolar disorder (Z=0.78, p=0.43). LIMITATION: Neuropsychological testing was not performed and we see it as an important limitation of this study. CONCLUSION: This population-based study further reinforces the notion that functional impairment is a fundamental characteristic of bipolar illness. It is present from early stages and is not completely explained by mood symptoms.
Authors: Taiane de Azevedo Cardoso; Thaise Campos Mondin; Carolina David Wiener; Melina Bazili Marques; Briane de Ávila Fucolo; Ricardo Tavares Pinheiro; Luciano Dias Mattos de Souza; Ricardo Azevedo da Silva; Karen Jansen; Jean Pierre Oses Journal: Neurochem Res Date: 2014-06-05 Impact factor: 3.996
Authors: Clarisse de Azambuja Farias; Taiane de Azevedo Cardoso; Marielle Moro da Silva; Francesca D'Angelo; Thaise Campos Mondin; Luciano Dias de Mattos Souza; Ricardo Azevedo da Silva; Flavio Kapczinski; Karen Jansen; Pedro V S Magalhães Journal: Front Psychiatry Date: 2022-08-24 Impact factor: 5.435
Authors: Joanne S Carpenter; Frank Iorfino; Shane Cross; Alissa Nichles; Natalia Zmicerevska; Jacob J Crouse; Jake R Palmer; Alexis E Whitton; Django White; Sharon L Naismith; Adam J Guastella; Daniel F Hermens; Jan Scott; Elizabeth M Scott; Ian B Hickie Journal: BMJ Open Date: 2020-03-29 Impact factor: 2.692