Literature DB >> 22950383

NFAT gene family in inflammation and cancer.

M-G Pan1, Y Xiong, F Chen.   

Abstract

Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.

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Year:  2013        PMID： 22950383      PMCID： PMC3694398          DOI： 10.2174/1566524011313040007

Source DB:  PubMed          Journal:  Curr Mol Med        ISSN： 1566-5240            Impact factor:   2.222


  120 in total

1.  Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.

Authors:  J Zhu; F Shibasaki; R Price; J C Guillemot; T Yano; V Dötsch; G Wagner; P Ferrara; F McKeon
Journal:  Cell       Date:  1998-05-29       Impact factor: 41.582

2.  Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.

Authors:  C W Chow; M Rincón; J Cavanagh; M Dickens; R J Davis
Journal:  Science       Date:  1997-11-28       Impact factor: 47.728

3.  Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

Authors:  C R Beals; N A Clipstone; S N Ho; G R Crabtree
Journal:  Genes Dev       Date:  1997-04-01       Impact factor: 11.361

4.  Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

Authors:  J Liu; J D Farmer; W S Lane; J Friedman; I Weissman; S L Schreiber
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

5.  Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.

Authors:  A L Armesilla; E Lorenzo; P Gómez del Arco; S Martínez-Martínez; A Alfranca; J M Redondo
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

6.  Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.

Authors:  C R Beals; C M Sheridan; C W Turck; P Gardner; G R Crabtree
Journal:  Science       Date:  1997-03-28       Impact factor: 47.728

7.  Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

Authors:  A M Ranger; M Oukka; J Rengarajan; L H Glimcher
Journal:  Immunity       Date:  1998-11       Impact factor: 31.745

8.  An enhanced immune response in mice lacking the transcription factor NFAT1.

Authors:  S Xanthoudakis; J P Viola; K T Shaw; C Luo; J D Wallace; P T Bozza; D C Luk; T Curran; A Rao
Journal:  Science       Date:  1996-05-10       Impact factor: 47.728

9.  The transcription factor NFAT4 is involved in the generation and survival of T cells.

Authors:  M Oukka; I C Ho; F C de la Brousse; T Hoey; M J Grusby; L H Glimcher
Journal:  Immunity       Date:  1998-09       Impact factor: 31.745

10.  Cain, a novel physiologic protein inhibitor of calcineurin.

Authors:  M M Lai; P E Burnett; H Wolosker; S Blackshaw; S H Snyder
Journal:  J Biol Chem       Date:  1998-07-17       Impact factor: 5.157
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  62 in total

Review 1.  Ca2+ as a therapeutic target in cancer.

Authors:  Scott Gross; Pranava Mallu; Hinal Joshi; Bryant Schultz; Christina Go; Jonathan Soboloff
Journal:  Adv Cancer Res       Date:  2020-07-09       Impact factor: 6.242

Review 2.  The role of nuclear factor of activated T cells in pulmonary arterial hypertension.

Authors:  Rui Chen; Jinchuan Yan; Peijing Liu; Zhongqun Wang; Cuiping Wang; Wei Zhong; Liangjie Xu
Journal:  Cell Cycle       Date:  2017-01-19       Impact factor: 4.534

Review 3.  Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Authors:  Volker M Lauschke; Yitian Zhou; Magnus Ingelman-Sundberg
Journal:  Pharmacol Ther       Date:  2019-01-22       Impact factor: 12.310

Review 4.  Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression.

Authors:  Lorenzo Federico; Kang Jin Jeong; Christopher P Vellano; Gordon B Mills
Journal:  J Lipid Res       Date:  2015-05-14       Impact factor: 5.922

5.  Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.

Authors:  P Tripathi; Y Wang; M Coussens; K R Manda; A M Casey; C Lin; E Poyo; J D Pfeifer; N Basappa; C M Bates; L Ma; H Zhang; M Pan; L Ding; F Chen
Journal:  Oncogene       Date:  2013-04-29       Impact factor: 9.867

Review 6.  NFAT as cancer target: mission possible?

Authors:  Jiang-Jiang Qin; Subhasree Nag; Wei Wang; Jianwei Zhou; Wei-Dong Zhang; Hui Wang; Ruiwen Zhang
Journal:  Biochim Biophys Acta       Date:  2014-07-26

7.  NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis.

Authors:  Einav Shoshan; Russell R Braeuer; Takafumi Kamiya; Aaron K Mobley; Li Huang; Mayra E Vasquez; Guermarie Velazquez-Torres; Nitin Chakravarti; Cristina Ivan; Victor Prieto; Gabriel J Villares; Menashe Bar-Eli
Journal:  Cancer Res       Date:  2016-03-24       Impact factor: 12.701

8.  The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis.

Authors:  Richard T Waldron; Yafeng Chen; Hung Pham; Ariel Go; Hsin-Yuan Su; Cheng Hu; Li Wen; Sohail Z Husain; Catherine A Sugar; Jack Roos; Stephanie Ramos; Aurelia Lugea; Michael Dunn; Kenneth Stauderman; Stephen J Pandol
Journal:  J Physiol       Date:  2019-05-22       Impact factor: 5.182

Review 9.  B Cell-Activating Factor (BAFF)-Targeted B Cell Therapies in Inflammatory Bowel Diseases.

Authors:  Mathieu Uzzan; Jean-Frederic Colombel; Andrea Cerutti; Xavier Treton; Saurabh Mehandru
Journal:  Dig Dis Sci       Date:  2016-09-21       Impact factor: 3.199

10.  Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors.

Authors:  Flor P Castro-García; Karla F Corral-Jara; Griselda Escobedo-Melendez; Monserrat A Sandoval-Hernandez; Yvonne Rosenstein; Sonia Roman; Arturo Panduro; Nora A Fierro
Journal:  Immunology       Date:  2014-12       Impact factor: 7.397
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