Literature DB >> 22948997

Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.

Pedro Cuevas1, Luis Outeiriño, Carlos Azanza, Guillermo Giménez-Gallego.   

Abstract

This case report presents the effectiveness of intravitreal administration of dobesilate, a synthetic fibroblast growth factor inhibitor, in two patients showing neovascular age-related macular degeneration of the classic, and of the occult choroidal neovascularisation types, respectively. Our study demonstrates that the treatment induces the regression of both forms of this pathology, as assessed by spectral optical coherence tomography. Improvement of the lesions was accompanied of visual acuity improvement.

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Year:  2012        PMID： 22948997      PMCID： PMC4543404          DOI： 10.1136/bcr-2012-006619

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  42 in total

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Authors:  Pedro Cuevas; Javier Angulo; Guillermo Giménez-Gallego
Journal:  BMJ Case Rep       Date:  2011-08-11

5.  Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism.

Authors:  T Andrew Clayton; David Baker; John C Lindon; Jeremy R Everett; Jeremy K Nicholson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-10       Impact factor: 11.205

6.  Enterotypes of the human gut microbiome.

Authors:  Manimozhiyan Arumugam; Jeroen Raes; Eric Pelletier; Denis Le Paslier; Takuji Yamada; Daniel R Mende; Gabriel R Fernandes; Julien Tap; Thomas Bruls; Jean-Michel Batto; Marcelo Bertalan; Natalia Borruel; Francesc Casellas; Leyden Fernandez; Laurent Gautier; Torben Hansen; Masahira Hattori; Tetsuya Hayashi; Michiel Kleerebezem; Ken Kurokawa; Marion Leclerc; Florence Levenez; Chaysavanh Manichanh; H Bjørn Nielsen; Trine Nielsen; Nicolas Pons; Julie Poulain; Junjie Qin; Thomas Sicheritz-Ponten; Sebastian Tims; David Torrents; Edgardo Ugarte; Erwin G Zoetendal; Jun Wang; Francisco Guarner; Oluf Pedersen; Willem M de Vos; Søren Brunak; Joel Doré; María Antolín; François Artiguenave; Hervé M Blottiere; Mathieu Almeida; Christian Brechot; Carlos Cara; Christian Chervaux; Antonella Cultrone; Christine Delorme; Gérard Denariaz; Rozenn Dervyn; Konrad U Foerstner; Carsten Friss; Maarten van de Guchte; Eric Guedon; Florence Haimet; Wolfgang Huber; Johan van Hylckama-Vlieg; Alexandre Jamet; Catherine Juste; Ghalia Kaci; Jan Knol; Omar Lakhdari; Severine Layec; Karine Le Roux; Emmanuelle Maguin; Alexandre Mérieux; Raquel Melo Minardi; Christine M'rini; Jean Muller; Raish Oozeer; Julian Parkhill; Pierre Renault; Maria Rescigno; Nicolas Sanchez; Shinichi Sunagawa; Antonio Torrejon; Keith Turner; Gaetana Vandemeulebrouck; Encarna Varela; Yohanan Winogradsky; Georg Zeller; Jean Weissenbach; S Dusko Ehrlich; Peer Bork
Journal:  Nature       Date:  2011-04-20       Impact factor: 49.962

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Journal:  Mol Neurobiol       Date:  2005-08       Impact factor: 5.590

8.  Persisent ocular hypertension following intravitreal ranibizumab.

Authors:  Sophie J Bakri; Colin A McCannel; Albert O Edwards; Darius M Moshfeghi
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-04-19       Impact factor: 3.117

Review 9.  Role and therapeutic potential of VEGF in the nervous system.

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10.  Ultrastructural findings in the primate eye after intravitreal injection of bevacizumab.

Authors:  Swaantje Peters; Peter Heiduschka; Sylvie Julien; Focke Ziemssen; Heike Fietz; Karl Ulrich Bartz-Schmidt; Ulrich Schraermeyer
Journal:  Am J Ophthalmol       Date:  2007-04-23       Impact factor: 5.258
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  3 in total

1.  Treatment of Stargardt disease with dobesilate.

Authors:  Pedro Cuevas; Luis A Outeiriño; Javier Angulo; Guillermo Giménez-Gallego
Journal:  BMJ Case Rep       Date:  2012-10-12

2.  Durable recovery of the macular architecture and functionality of a diagnosed age-related macular degeneration 1 year after a single intravitreal injection of dobesilate.

Authors:  P Cuevas; L A Outeiriño; C Azanza; G Giménez-Gallego
Journal:  BMJ Case Rep       Date:  2013-11-13

3.  Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate.

Authors:  Pedro Cuevas; Luis Antonio Outeiriño; Carlos Azanza; Javier Angulo; Guillermo Giménez-Gallego
Journal:  Mil Med Res       Date:  2015-09-08
  3 in total

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