Literature DB >> 22948885

Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium.

Romney M Humphries1, Theodoros Kelesidis, Ryan Tewhey, Warren E Rose, Nicholas Schork, Victor Nizet, George Sakoulas.   

Abstract

Whole-genome sequencing and cell membrane studies of three clonal Enterococcus faecium strains with daptomycin MICs of 4, 32, and 192 μg/ml were performed, revealing nonsynonymous single nucleotide variants in eight open reading frames, including those predicted to encode a phosphoenolpyruvate-dependent, mannose-specific phosphotransferase system, cardiolipin synthetase, and EzrA. Membrane studies revealed a higher net surface charge among the daptomycin-nonsusceptible isolates and increased septum formation in the isolate with a daptomycin MIC of 192 μg/ml.

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Year:  2012        PMID： 22948885      PMCID： PMC3486580          DOI： 10.1128/AAC.01318-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  21 in total

1.  Class II one-peptide bacteriocins target a phylogenetically defined subgroup of mannose phosphotransferase systems on sensitive cells.

Authors:  Morten Kjos; Ingolf F Nes; Dzung B Diep
Journal:  Microbiology (Reading)       Date:  2009-05-28       Impact factor: 2.777

Review 2.  Bacterial cell division: assembly, maintenance and disassembly of the Z ring.

Authors:  David W Adams; Jeff Errington
Journal:  Nat Rev Microbiol       Date:  2009-09       Impact factor: 60.633

3.  Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium.

Authors:  George Sakoulas; Arnold S Bayer; Joseph Pogliano; Brian T Tsuji; Soo-Jin Yang; Nagendra N Mishra; Victor Nizet; Michael R Yeaman; Pamela A Moise
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

4.  In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity.

Authors:  A S Bayer; R Prasad; J Chandra; A Koul; M Smriti; A Varma; R A Skurray; N Firth; M H Brown; S P Koo; M R Yeaman
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

5.  Biochemical and genetic evidence that Enterococcus faecium L50 produces enterocins L50A and L50B, the sec-dependent enterocin P, and a novel bacteriocin secreted without an N-terminal extension termed enterocin Q.

Authors:  L M Cintas; P Casaus; C Herranz; L S Hâvarstein; H Holo; P E Hernández; I F Nes
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

6.  Genetic basis for daptomycin resistance in enterococci.

Authors:  Kelli L Palmer; Anu Daniel; Crystal Hardy; Jared Silverman; Michael S Gilmore
Journal:  Antimicrob Agents Chemother       Date:  2011-04-18       Impact factor: 5.191

7.  De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computer.

Authors:  David Hernandez; Patrice François; Laurent Farinelli; Magne Osterås; Jacques Schrenzel
Journal:  Genome Res       Date:  2008-03-10       Impact factor: 9.043

8.  De novo daptomycin-nonsusceptible enterococcal infections.

Authors:  Theodoros Kelesidis; Romney Humphries; Daniel Z Uslan; David Pegues
Journal:  Emerg Infect Dis       Date:  2012-04       Impact factor: 16.126

9.  A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries.

Authors:  Sheila Fisher; Andrew Barry; Justin Abreu; Brian Minie; Jillian Nolan; Toni M Delorey; Geneva Young; Timothy J Fennell; Alexander Allen; Lauren Ambrogio; Aaron M Berlin; Brendan Blumenstiel; Kristian Cibulskis; Dennis Friedrich; Ryan Johnson; Frank Juhn; Brian Reilly; Ramy Shammas; John Stalker; Sean M Sykes; Jon Thompson; John Walsh; Andrew Zimmer; Zac Zwirko; Stacey Gabriel; Robert Nicol; Chad Nusbaum
Journal:  Genome Biol       Date:  2011-01-04       Impact factor: 13.583

10.  Fast and accurate short read alignment with Burrows-Wheeler transform.

Authors:  Heng Li; Richard Durbin
Journal:  Bioinformatics       Date:  2009-05-18       Impact factor: 6.937
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  37 in total

Review 1.  Mechanisms of drug resistance: daptomycin resistance.

Authors:  Truc T Tran; Jose M Munita; Cesar A Arias
Journal:  Ann N Y Acad Sci       Date:  2015-10-23       Impact factor: 5.691

2.  Fosfomycin Enhances the Activity of Daptomycin against Vancomycin-Resistant Enterococci in an In Vitro Pharmacokinetic-Pharmacodynamic Model.

Authors:  Ashley D Hall Snyder; Brian J Werth; Poochit Nonejuie; John P McRoberts; Joe Pogliano; George Sakoulas; Juwon Yim; Nivedita Singh; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

3.  Variability of Daptomycin MIC Values for Enterococcus faecium When Measured by Reference Broth Microdilution and Gradient Diffusion Tests.

Authors:  Shelley A Campeau; Audrey N Schuetz; Peggy Kohner; Cesar A Arias; Peera Hemarajata; Jennifer Dien Bard; Romney M Humphries
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

Review 4.  Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci.

Authors:  William R Miller; Arnold S Bayer; Cesar A Arias
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915

5.  β-Lactams enhance daptomycin activity against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium in in vitro pharmacokinetic/pharmacodynamic models.

Authors:  Jordan R Smith; Katie E Barber; Animesh Raut; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2015-03-09       Impact factor: 5.191

Review 6.  A current perspective on daptomycin for the clinical microbiologist.

Authors:  Romney M Humphries; Simon Pollett; George Sakoulas
Journal:  Clin Microbiol Rev       Date:  2013-10       Impact factor: 26.132

7.  Proximity to animal or crop operations may be associated with de novo daptomycin-non-susceptible Enterococcus infection.

Authors:  T Kelesidis; A L Chow
Journal:  Epidemiol Infect       Date:  2013-04-15       Impact factor: 2.451

8.  β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium.

Authors:  Jordan R Smith; Katie E Barber; Animesh Raut; Mostafa Aboutaleb; George Sakoulas; Michael J Rybak
Journal:  J Antimicrob Chemother       Date:  2015-02-01       Impact factor: 5.790

Review 9.  [Resistance to "last resort" antibiotics in Gram-positive cocci: The post-vancomycin era].

Authors:  Sandra Rincón; Diana Panesso; Lorena Díaz; Lina P Carvajal; Jinnethe Reyes; José M Munita; César A Arias
Journal:  Biomedica       Date:  2014-04       Impact factor: 0.935

10.  Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium.

Authors:  George Sakoulas; Warren Rose; Poochit Nonejuie; Joshua Olson; Joseph Pogliano; Romney Humphries; Victor Nizet
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191
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