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Literature DB >> 22948164

Chromosomal translocations among the healthy human population: implications in oncogenesis.

Abstract

Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried out in different geographical areas of the world and discuss the relevance of the observation with respect to oncogenesis.

Entities: Disease Species

Mesh：

Year: 2012 PMID： 22948164 DOI： 10.1007/s00018-012-1135-x

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

109 in total

1. t(14;18) Translocations and risk of follicular lymphoma.

Authors: Charles S Rabkin; Carsten Hirt; Siegfried Janz; Gottfried Dölken
Journal: J Natl Cancer Inst Monogr Date: 2008

2. Pesticide appliers with mixed pesticide exposure: G-banded analysis and possible relationship to non-Hodgkin's lymphoma.

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Journal: Cancer Epidemiol Biomarkers Prev Date: 1996-01 Impact factor: 4.254

3. Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.

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Journal: EMBO J Date: 2005-08-11 Impact factor: 11.598

4. Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home.

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Journal: Radiat Res Date: 1996-01 Impact factor: 2.841

5. Detection of t(14;18) carrying cells in bone marrow and peripheral blood from patients affected by non-lymphoid diseases.

Authors: O Rauzy; S Galoin; J J Chale; D Adoue; J L Albarede; G Delsol; T al Saati
Journal: Mol Pathol Date: 1998-12

Review 6. Pesticides and non-Hodgkin's lymphoma.

Authors: S H Zahm; A Blair
Journal: Cancer Res Date: 1992-10-01 Impact factor: 12.701

7. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation.

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Journal: Nature Date: 1985 May 23-29 Impact factor: 49.962

Review 8. Chromosomal translocations in cancer.

Authors: Mridula Nambiar; Vijayalakshmi Kari; Sathees C Raghavan
Journal: Biochim Biophys Acta Date: 2008-07-31

9. MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals.

Authors: María Sol Brassesco; Ana Paula Montaldi; Diana Ester Gras; Rosane Gomes de Paula Queiroz; Nilce Maria Martinez-Rossi; Luiz Gonzaga Tone; Elza Tiemi Sakamoto-Hojo
Journal: Genet Mol Biol Date: 2009-06-01 Impact factor: 1.771

10. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

Authors: B H Ye; S Chaganti; C C Chang; H Niu; P Corradini; R S Chaganti; R Dalla-Favera
Journal: EMBO J Date: 1995-12-15 Impact factor: 11.598

12 in total

1. Methylation of CpG sites in BCL2 major breakpoint region and the increase of BCL2/JH translocation with aging.

Authors: Idoia Martin-Guerrero; Elena de Prado; Maite Ardanaz; Maialen Martin-Arruti; Cristina Garcia-Orad; Isabel Guerra; Irune Ruiz; Iñaki Zabalza; Africa Garcia-Orad
Journal: Age (Dordr) Date: 2015-09-03

2. Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

Authors: Idoia Martín-Guerrero; Elena de Prado; Elixabet Lopez-Lopez; Maite Ardanaz; Juan Carlos Vitoria; Luis A Parada; Cristina García-Orad; Africa García-Orad
Journal: Age (Dordr) Date: 2014-11-16

3. Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor.

Authors: Namrata M Nilavar; Amita M Paranjape; Sathees C Raghavan
Journal: Cell Death Discov Date: 2020-06-12

4. Preventing clonal evolutionary processes in cancer: Insights from mathematical models.

Authors: Ignacio A Rodriguez-Brenes; Dominik Wodarz
Journal: Proc Natl Acad Sci U S A Date: 2015-07-21 Impact factor: 11.205

5. Copy number variation burden on asthma subgenome in normal cohorts identifies susceptibility markers.

Authors: Sangeetha Vishweswaraiah; Avinash M Veerappa; Padukudru A Mahesh; Sareh R Jahromi; Nallur B Ramachandra
Journal: Allergy Asthma Immunol Res Date: 2014-12-18 Impact factor: 5.764

6. Integrated sequence and expression analysis of ovarian cancer structural variants underscores the importance of gene fusion regulation.

Authors: Vinay K Mittal; John F McDonald
Journal: BMC Med Genomics Date: 2015-07-17 Impact factor: 3.063