Literature DB >> 22948145

Structure and mode of peptide binding of pheromone receptor PrgZ.

Ronnie P-A Berntsson1, Gea K Schuurman-Wolters, Gary Dunny, Dirk-Jan Slotboom, Bert Poolman.   

Abstract

We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.

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Year:  2012        PMID： 22948145      PMCID： PMC3481316          DOI： 10.1074/jbc.M112.386334

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  34 in total

1.  General quadratic functions in real and reciprocal space and their application to likelihood phasing.

Authors:  K Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2000-12

Review 2.  A structural classification of substrate-binding proteins.

Authors:  Ronnie P-A Berntsson; Sander H J Smits; Lutz Schmitt; Dirk-Jan Slotboom; Bert Poolman
Journal:  FEBS Lett       Date:  2010-04-20       Impact factor: 4.124

3.  Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.

Authors:  Ke Shi; C Kent Brown; Zu-Yi Gu; Briana K Kozlowicz; Gary M Dunny; Douglas H Ohlendorf; Cathleen A Earhart
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-08       Impact factor: 11.205

4.  High-throughput cloning and expression in recalcitrant bacteria.

Authors:  Eric R Geertsma; Bert Poolman
Journal:  Nat Methods       Date:  2007-07-22       Impact factor: 28.547

5.  Direct evidence for control of the pheromone-inducible prgQ operon of Enterococcus faecalis plasmid pCF10 by a countertranscript-driven attenuation mechanism.

Authors:  Christopher M Johnson; Dawn A Manias; Heather A H Haemig; Sonia Shokeen; Keith E Weaver; Tina M Henkin; Gary M Dunny
Journal:  J Bacteriol       Date:  2010-01-22       Impact factor: 3.490

6.  Rapid measurement of binding constants and heats of binding using a new titration calorimeter.

Authors:  T Wiseman; S Williston; J F Brandts; L N Lin
Journal:  Anal Biochem       Date:  1989-05-15       Impact factor: 3.365

7.  Analysis of expression of prgX, a key negative regulator of the transfer of the Enterococcus faecalis pheromone-inducible plasmid pCF10.

Authors:  T Bae; S Clerc-Bardin; G M Dunny
Journal:  J Mol Biol       Date:  2000-04-07       Impact factor: 5.469

8.  Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation.

Authors:  B A Leonard; A Podbielski; P J Hedberg; G M Dunny
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

9.  MolProbity: all-atom structure validation for macromolecular crystallography.

Authors:  Vincent B Chen; W Bryan Arendall; Jeffrey J Headd; Daniel A Keedy; Robert M Immormino; Gary J Kapral; Laura W Murray; Jane S Richardson; David C Richardson
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-12-21

10.  BALBES: a molecular-replacement pipeline.

Authors:  Fei Long; Alexei A Vagin; Paul Young; Garib N Murshudov
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2007-12-05
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  6 in total

Review 1.  Possible drugs for the treatment of bacterial infections in the future: anti-virulence drugs.

Authors:  Hiroshi Ogawara
Journal:  J Antibiot (Tokyo)       Date:  2020-07-09       Impact factor: 2.649

Review 2.  Enterococcal Sex Pheromones: Evolutionary Pathways to Complex, Two-Signal Systems.

Authors:  Gary M Dunny; Ronnie Per-Arne Berntsson
Journal:  J Bacteriol       Date:  2016-05-13       Impact factor: 3.490

3.  Oligopeptide-binding protein from nontypeable Haemophilus influenzae has ligand-specific sites to accommodate peptides and heme in the binding pocket.

Authors:  Kari J Tanaka; Heather W Pinkett
Journal:  J Biol Chem       Date:  2018-11-19       Impact factor: 5.157

4.  Two ABC transport systems carry out peptide uptake in Enterococcus faecalis: Their roles in growth and in uptake of sex pheromones.

Authors:  Takaya Segawa; Christopher M Johnson; Ronnie P-A Berntsson; Gary M Dunny
Journal:  Mol Microbiol       Date:  2021-04-19       Impact factor: 3.979

5.  Mechanisms of peptide sex pheromone regulation of conjugation in Enterococcus faecalis.

Authors:  Yuqing Chen; Arpan Bandyopadhyay; Briana K Kozlowicz; Heather A H Haemig; Albert Tai; Wei-Shou Hu; Gary M Dunny
Journal:  Microbiologyopen       Date:  2017-05-19       Impact factor: 3.139

Review 6.  Competent but complex communication: The phenomena of pheromone-responsive plasmids.

Authors:  Amy J Sterling; William J Snelling; Patrick J Naughton; Nigel G Ternan; James S G Dooley
Journal:  PLoS Pathog       Date:  2020-04-02       Impact factor: 6.823
  6 in total

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