| Literature DB >> 22944304 |
Abstract
Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in the clinical setting. Due to the rising number of compounds having solubility issues, finding ways to enhance the solubility of drugs is one of the major challenges in the pharmaceutical industry today. Polymeric micelles, which form upon self-assembly of amphiphilic macromolecules, can act as solubilizing agents for delivery of poorly soluble drugs. This manuscript examines the fundamentals of polymeric micelles through reviews of representative literature and demonstrates possible applications through recent examples of clinical trial developments. In particular, the potential of polymeric micelles for delivery of poorly water-soluble drugs, especially in the areas of oral delivery and in cancer therapy, is discussed. Key considerations in utilizing polymeric micelles' advantages and overcoming potential disadvantages have been highlighted. Lastly, other possible strategies related to particle size reduction for enhancing solubilization of poorly water-soluble drugs are introduced.Entities:
Keywords: Anticancer; Clinical trial; Drug solubilization; Micelle stability; Nanocrystal; Nanoemulsion; Oral delivery; Polymeric micelle
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Year: 2012 PMID： 22944304 PMCID： PMC3760723 DOI： 10.1016/j.ijpharm.2012.08.042
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875