Literature DB >> 22942282

Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase.

Kristin E Burns1, Fiona E McAllister, Carsten Schwerdtfeger, Julian Mintseris, Francisca Cerda-Maira, Elke E Noens, Matthias Wilmanns, Stevan R Hubbard, Francesco Melandri, Huib Ovaa, Steven P Gygi, K Heran Darwin.   

Abstract

Deamidase of Pup (Dop), the prokaryotic ubiquitin-like protein (Pup)-deconjugating enzyme, is critical for the full virulence of Mycobacterium tuberculosis and is unique to bacteria, providing an ideal target for the development of selective chemotherapies. We used a combination of genetics and chemical biology to characterize the mechanism of depupylation. We identified an aspartate as a potential nucleophile in the active site of Dop, suggesting a novel protease activity to target for inhibitor development.

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Year:  2012        PMID： 22942282      PMCID： PMC3481346          DOI： 10.1074/jbc.M112.384784

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  37 in total

1.  Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.

Authors:  Anna Borodovsky; Huib Ovaa; Nagamalleswari Kolli; Tudeviin Gan-Erdene; Keith D Wilkinson; Hidde L Ploegh; Benedikt M Kessler
Journal:  Chem Biol       Date:  2002-10

2.  The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus.

Authors:  Frank Striebel; Moritz Hunkeler; Heike Summer; Eilika Weber-Ban
Journal:  EMBO J       Date:  2010-03-04       Impact factor: 11.598

3.  Activity of the mycobacterial proteasomal ATPase Mpa is reversibly regulated by pupylation.

Authors:  Cyrille L Delley; Frank Striebel; Franziska M Heydenreich; Dennis Özcelik; Eilika Weber-Ban
Journal:  J Biol Chem       Date:  2011-12-30       Impact factor: 5.157

4.  "Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates.

Authors:  Kristin E Burns; Francisca A Cerda-Maira; Tao Wang; Huilin Li; William R Bishai; K Heran Darwin
Journal:  Mol Cell       Date:  2010-08-12       Impact factor: 17.970

5.  Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis.

Authors:  Francisca A Cerda-Maira; Michael J Pearce; Michele Fuortes; William R Bishai; Stevan R Hubbard; K Heran Darwin
Journal:  Mol Microbiol       Date:  2010-09       Impact factor: 3.501

6.  Direct chemical evidence for the mixed anhydride intermediate of carboxypeptidase A in ester and peptide hydrolysis.

Authors:  M E Sander; H Witzel
Journal:  Biochem Biophys Res Commun       Date:  1985-10-30       Impact factor: 3.575

7.  YbdK is a carboxylate-amine ligase with a gamma-glutamyl:Cysteine ligase activity: crystal structure and enzymatic assays.

Authors:  Christopher Lehmann; Victoria Doseeva; Sadhana Pullalarevu; Wojciech Krajewski; Andrew Howard; Osnat Herzberg
Journal:  Proteins       Date:  2004-08-01

8.  Unified picture of mechanisms of catalysis by carboxypeptidase A.

Authors:  R Breslow; D L Wernick
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

9.  Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain.

Authors:  Elke E Noens; Chris Williams; Madhankumar Anandhakrishnan; Christian Poulsen; Matthias T Ehebauer; Matthias Wilmanns
Journal:  BMC Biotechnol       Date:  2011-03-25       Impact factor: 2.563

10.  Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis.

Authors:  Remco Merkx; Kristin E Burns; Paul Slobbe; Farid El Oualid; Dris El Atmioui; K Heran Darwin; Huib Ovaa
Journal:  Chembiochem       Date:  2012-08-24       Impact factor: 3.164
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  11 in total

Review 1.  Bacterial Proteasomes: Mechanistic and Functional Insights.

Authors:  Samuel H Becker; K Heran Darwin
Journal:  Microbiol Mol Biol Rev       Date:  2016-12-14       Impact factor: 11.056

Review 2.  Bacterial Proteasomes.

Authors:  Jordan B Jastrab; K Heran Darwin
Journal:  Annu Rev Microbiol       Date:  2015       Impact factor: 15.500

Review 3.  The Pup-Proteasome System of Mycobacteria.

Authors:  Nadine J Bode; K Heran Darwin
Journal:  Microbiol Spectr       Date:  2014-10

4.  Depupylase Dop Requires Inorganic Phosphate in the Active Site for Catalysis.

Authors:  Marcel Bolten; Christian Vahlensieck; Colette Lipp; Marc Leibundgut; Nenad Ban; Eilika Weber-Ban
Journal:  J Biol Chem       Date:  2017-01-24       Impact factor: 5.157

Review 5.  Prokaryotic ubiquitin-like protein modification.

Authors:  Julie A Maupin-Furlow
Journal:  Annu Rev Microbiol       Date:  2014-05-29       Impact factor: 15.500

Review 6.  Prokaryotic proteasomes: nanocompartments of degradation.

Authors:  Matthew A Humbard; Julie A Maupin-Furlow
Journal:  J Mol Microbiol Biotechnol       Date:  2013-08-05

7.  Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates.

Authors:  Susan Zhang; Kristin E Burns-Huang; Guido V Janssen; Huilin Li; Huib Ovaa; Lizbeth Hedstrom; K Heran Darwin
Journal:  mBio       Date:  2017-02-21       Impact factor: 7.867

8.  Pupylated proteins are subject to broad proteasomal degradation specificity and differential depupylation.

Authors:  Juerg Laederach; Hengjun Cui; Eilika Weber-Ban
Journal:  PLoS One       Date:  2019-04-22       Impact factor: 3.240

Review 9.  The pupylation pathway and its role in mycobacteria.

Authors:  Jonas Barandun; Cyrille L Delley; Eilika Weber-Ban
Journal:  BMC Biol       Date:  2012-11-30       Impact factor: 7.431

10.  Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System*.

Authors:  Guido V Janssen; Susan Zhang; Remco Merkx; Christa Schiesswohl; Champak Chatterjee; K Heran Darwin; Paul P Geurink; Gerbrand J van der Heden van Noort; Huib Ovaa
Journal:  Chembiochem       Date:  2021-09-12       Impact factor: 3.164
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