| Literature DB >> 22940416 |
Johanna Ungersboeck1, Cecile Philippe, Daniela Haeusler, Markus Mitterhauser, Rupert Lanzenberger, Robert Dudczak, Wolfgang Wadsak.
Abstract
The intention for the present study was to implement a microfluidic set-up for N-(11)C-methylations in a flow-through microreactor device with [(11)C]DASB as model-compound and [(11)C]CH(3)I and [(11)C]CH(3)OTf, respectively, as (11)C-methylation agents. Due to an observed "aging" effect of the (11)C-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [(11)C]DASB was reduced (34±1 min) and RCY was increased to 45.1±4.6% (EOB; 5.2±0.95 GBq EOS).Entities:
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Year: 2012 PMID： 22940416 DOI： 10.1016/j.apradiso.2012.08.001
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513