Literature DB >> 22939990

PGC-1 proteins and heart failure.

Christian Riehle1, E Dale Abel.   

Abstract

The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22939990      PMCID： PMC3466400          DOI： 10.1016/j.tcm.2012.07.003

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  54 in total

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  41 in total

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Journal:  J Physiol       Date:  2016-12-01       Impact factor: 5.182

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Authors:  Renata O Pereira; Adam R Wende; Ashley Crum; Douglas Hunter; Curtis D Olsen; Tenley Rawlings; Christian Riehle; Walter F Ward; E Dale Abel
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4.  Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ.

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