Literature DB >> 22939614

Singles engage the RNA interference pathway.

Beverly L Davidson, Alex Mas Monteys.   

Abstract

Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.
Copyright © 2012 Elsevier Inc. All rights reserved.

Year:  2012        PMID： 22939614     DOI： 10.1016/j.cell.2012.08.008

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  7 in total

1.  Taking a break from huntingtin.

Authors:  Beverly L Davidson
Journal:  Mol Ther       Date:  2012-10       Impact factor: 11.454

Review 2.  Recent advances in RNA interference therapeutics for CNS diseases.

Authors:  Pavitra S Ramachandran; Megan S Keiser; Beverly L Davidson
Journal:  Neurotherapeutics       Date:  2013-07       Impact factor: 7.620

3.  Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease.

Authors:  Lisa M Stanek; Sergio P Sardi; Bryan Mastis; Amy R Richards; Christopher M Treleaven; Tatyana Taksir; Kuma Misra; Seng H Cheng; Lamya S Shihabuddin
Journal:  Hum Gene Ther       Date:  2014-03-21       Impact factor: 5.695

Review 4.  Huntington's disease: underlying molecular mechanisms and emerging concepts.

Authors:  John Labbadia; Richard I Morimoto
Journal:  Trends Biochem Sci       Date:  2013-06-12       Impact factor: 13.807

Review 5.  Gene regulation by non-coding RNAs.

Authors:  Veena S Patil; Rui Zhou; Tariq M Rana
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-10-28       Impact factor: 8.250

6.  Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.

Authors:  Valérie Drouet; Marta Ruiz; Diana Zala; Maxime Feyeux; Gwennaëlle Auregan; Karine Cambon; Laetitia Troquier; Johann Carpentier; Sophie Aubert; Nicolas Merienne; Fany Bourgois-Rocha; Raymonde Hassig; Maria Rey; Noëlle Dufour; Frédéric Saudou; Anselme L Perrier; Philippe Hantraye; Nicole Déglon
Journal:  PLoS One       Date:  2014-06-13       Impact factor: 3.240

7.  Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain.

Authors:  Alex Mas Monteys; Ryan M Spengler; Brett D Dufour; Matt S Wilson; Clayton K Oakley; Matt J Sowada; Jodi L McBride; Beverly L Davidson
Journal:  Nucleic Acids Res       Date:  2014-10-20       Impact factor: 16.971
  7 in total

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